You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HUWE1
E3 ubiquitin-protein ligase HUWE1

Protein Summary
Description
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262854
  • ENSP00000262854
  • ENSG00000086758
  • ENST00000342160
  • ENSP00000340648
  • ENST00000612484
  • ENSP00000479451

Symbol
  • KIAA0312
  • KIAA1578
  • UREB1
  • MULE
  • Ib772
  • LASU1
  • UREB1
  • HECTH9
  • URE-B1
  • ARF-BP1
  • HSPC272
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.97
disease perturbation
0.9
kinase perturbation
0.84
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.92   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.92   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Innate Immune System
Protein-Protein Interactions (417)
1 – 10 of 417
UBC
Tbio
Novelty: 0.00161137
Score: 0.997
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00895161
Score: 0.997
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.996
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.01148413
Score: 0.996
Data Source: STRINGDB
PHAX
Tbio
Novelty: 0.06737247
Score: 0.976
Data Source: STRINGDB
UBE2D2
Tbio
Novelty: 0.00827182
Score: 0.975
Data Source: STRINGDB
UBA1
Tbio
Novelty: 0.00582285
Score: 0.97
Data Source: STRINGDB
HERC2
Tbio
Family: Enzyme
Novelty: 0.05519779
Score: 0.97
Data Source: STRINGDB
TRIP12
Tbio
Family: Enzyme
Novelty: 0.00653395
Score: 0.969
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00202514
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.92

PubMed score by year
PubTator Score  82.37

PubTator score by year
Amino Acid Sequence