Tbio HUWE1 E3 ubiquitin-protein ligase HUWE1

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Huwe1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Huwe1

Protein Summary

Description

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q7Z6Z7
• O15029
• Q4G2Z2
• Q5H961
• Q6P4D0
• Q8NG67
• Q9BUI0
• Q9HCJ4
• Q9NSL6
• Q9P0A9

Gene Name

• HUWE1

Ensembl ID

• ENST00000262854
• ENSP00000262854
• ENSG00000086758
• ENST00000342160
• ENSP00000340648
• ENST00000612484
• ENSP00000479451

Symbol

• KIAA0312
• KIAA1578
• UREB1
• MULE
• Ib772
• LASU1
• UREB1
• HECTH9
• URE-B1
• ARF-BP1
• HSPC272

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
transcription factor perturbation	0.97
disease perturbation	0.9
kinase perturbation	0.84
virus perturbation	0.83

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.92   (req: < 5)

Gene RIFs: 58   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.92   (req: >= 5)

Gene RIFs: 58   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (8)

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (11)

Reactome (6)

KEGG (1)

PathwayCommons (3)

UniProt (1)

Adaptive Immune System (R-HSA-1280218)

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Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Gene Ontology Terms (22)

Functions (4)

Components (9)

Processes (9)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
ubiquitin-protein transferase activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ubiquitin protein ligase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Protein-Protein Interactions (417)

Explore Interacting Targets

1 – 10 of 417

• See Interactions on String-DB

UBC

Tbio

Novelty: 0.00161137

Score: 0.997

Data Source: STRINGDB

UBB

Tbio

Novelty: 0.00895161

Score: 0.997

Data Source: STRINGDB

UBA52

Tbio

Novelty: 0.01006012

Score: 0.996

Data Source: STRINGDB

RPS27A

Tbio

Novelty: 0.01148413

Score: 0.996

Data Source: STRINGDB

PHAX

Tbio

Novelty: 0.06737247

Score: 0.976

Data Source: STRINGDB

UBE2D2

Tbio

Novelty: 0.00827182

Score: 0.975

Data Source: STRINGDB

UBA1

Tbio

Novelty: 0.00582285

Score: 0.97

Data Source: STRINGDB

HERC2

Tbio

Family: Enzyme

Novelty: 0.05519779

Score: 0.97

Data Source: STRINGDB

TRIP12

Tbio

Family: Enzyme

Novelty: 0.00653395

Score: 0.969

Data Source: STRINGDB

UBE2D1

Tbio

Novelty: 0.00202514

Score: 0.968

Data Source: STRINGDB

Publication Statistics

PubMed Score  131.92

PubMed score by year

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PubTator Score  82.37

PubTator score by year

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Amino Acid Sequence