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Tbio
SLC20A2
Sodium-dependent phosphate transporter 2

Protein Summary
Description
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342228
  • ENSP00000340465
  • ENSG00000168575
  • ENST00000520179
  • ENSP00000429712
  • ENST00000520262
  • ENSP00000429754

Symbol
  • GLVR2
  • PIT2
  • PIT2
  • RAM1
  • GLVR2
  • IBGC1
  • IBGC3
  • MLVAR
  • PIT-2
  • Ram-1
  • GLVR-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.85
transcription factor binding site profile
0.85
molecular function
0.84
virus perturbation
0.79
disease perturbation
0.74


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.87   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.87   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
97.1
self reported educational attainment
2
2
2
94.9
hemoglobin measurement
1
1
1
81.9
red blood cell density measurement
1
1
1
81.9
testosterone measurement
1
1
1
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
97.1
self reported educational attainment
2
94.9
hemoglobin measurement
1
81.9
red blood cell density measurement
1
81.9
testosterone measurement
1
65
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 20 member 2
VGNC:7738
100609712
Macaque
solute carrier family 20 member 2
705242
Mouse
MGI:97851
20516
Rat
RGD:3699
29502
Dog
solute carrier family 20 member 2
VGNC:46269
482838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 20 member 2
Macaque
solute carrier family 20 member 2
Mouse
Rat
Dog
solute carrier family 20 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q08357-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) (R-HSA-5619111)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (65)
1 – 10 of 65
ARMC6
Tdark
Novelty: 0.58706267
p_int: 0.999274285
p_ni: 0.000725706
p_wrong: 8e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
SLC20A1
Tbio
Family: Transporter
Novelty: 0.01123373
p_int: 0.996544089
p_ni: 0.003446654
p_wrong: 0.000009256
Score: 0.219
Data Source: BioPlex,STRINGDB
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
p_int: 0.989761004
p_ni: 0.007146941
p_wrong: 0.003092055
Score: 0.497
Data Source: BioPlex,STRINGDB
SYP
Tbio
Novelty: 0.00021543
p_int: 0.985182401
p_ni: 0.009305476
p_wrong: 0.005512123
Data Source: BioPlex
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.985182401
p_ni: 0.009305476
p_wrong: 0.005512123
Data Source: BioPlex
TOR1AIP2
Tbio
Novelty: 0.08912351
p_int: 0.978273705
p_ni: 0.010169497
p_wrong: 0.011556799
Data Source: BioPlex
AIFM1
Tbio
Novelty: 0.00940088
p_int: 0.978138218
p_ni: 0.006718942
p_wrong: 0.015142839
Score: 0.267
Data Source: BioPlex,STRINGDB
GGT5
Tbio
Family: Enzyme
Novelty: 0.00602505
p_int: 0.977693703
p_ni: 0.006732555
p_wrong: 0.015573742
Score: 0.227
Data Source: BioPlex,STRINGDB
PTGFR
Tclin
Family: GPCR
Novelty: 0.00560908
p_int: 0.922597151
p_ni: 0.060303096
p_wrong: 0.017099753
Score: 0.523
Data Source: BioPlex,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
p_int: 0.791886339
p_ni: 0.00129827
p_wrong: 0.206815391
Data Source: BioPlex
Publication Statistics
PubMed Score  273.87

PubMed score by year
PubTator Score  122.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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