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Tbio
MYB
Transcriptional activator Myb

Protein Summary
Description
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341911
  • ENSP00000339992
  • ENSG00000118513
  • ENST00000367812
  • ENSP00000356786
  • ENST00000367814
  • ENSP00000356788
  • ENST00000442647
  • ENSP00000410825
  • ENST00000525369
  • ENSP00000435938
  • ENST00000525477
  • ENSP00000437081
  • ENST00000525514
  • ENSP00000435578
  • ENST00000528774
  • ENSP00000434723
  • ENST00000529586
  • ENSP00000437264
  • ENST00000533384
  • ENSP00000432811
  • ENST00000533624
  • ENSP00000436605
  • ENST00000533808
  • ENSP00000435293
  • ENST00000533837
  • ENSP00000434639
  • ENST00000534044
  • ENSP00000435055
  • ENST00000534121
  • ENSP00000432851

Symbol
  • efg
  • Cmyb
  • c-myb
  • c-myb_CDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
PubMedID
0.99
gene perturbation
0.98
hub protein
0.97
transcription factor
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.78   (req: < 5)
Gene RIFs: 192   (req: <= 3)
Antibodies: 856   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.78   (req: >= 5)
Gene RIFs: 192   (req: > 3)
Antibodies: 856   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (26)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Developmental Biology
ESR-mediated signaling
Estrogen-dependent gene expression
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Protein-Protein Interactions (249)
1 – 10 of 249
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00127032
Score: 0.994
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.991
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.0009412
Score: 0.985
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00087325
Score: 0.981
Data Source: STRINGDB
LMO2
Tbio
Novelty: 0.00508219
Score: 0.979
Data Source: STRINGDB
NLK
Tchem
Family: Kinase
Novelty: 0.01797139
Score: 0.979
Data Source: STRINGDB
PAX5
Tbio
Family: TF
Novelty: 0.00169837
Score: 0.97
Data Source: STRINGDB
MAF
Tbio
Family: TF
Novelty: 0.00112851
Score: 0.969
Data Source: STRINGDB
CCND1
Tchem
Novelty: 0.0001425
Score: 0.967
Data Source: STRINGDB
TAL1
Tbio
Family: TF
Novelty: 0.00369378
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  987.78

PubMed score by year
PubTator Score  1080.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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