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Tbio
THBS4
Thrombospondin-4

Protein Summary
Description
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By simi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350881
  • ENSP00000339730
  • ENSG00000113296

Symbol
  • TSP4
  • TSP4
  • TSP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.81
biological process
0.8
gene perturbation
0.76
disease
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.93   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.93   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
1
2
90.8
smoking status measurement
2
1
2
76.1
intraocular pressure measurement
1
2
2
46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
90.8
smoking status measurement
2
76.1
intraocular pressure measurement
2
46
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thrombospondin 4
VGNC:4195
450172
Macaque
thrombospondin 4
574276
Mouse
MGI:1101779
21828
Rat
RGD:62046
29220
Dog
thrombospondin 4
VGNC:47338
488930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thrombospondin 4
Macaque
thrombospondin 4
Mouse
Rat
Dog
thrombospondin 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35443-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by PDGF
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by PDGF
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (23)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (65)
1 – 10 of 65
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.999975769
p_wrong: 0.000024231
Score: 0.24
Data Source: BioPlex,STRINGDB
MATN2
Tbio
Novelty: 0.08506252
p_int: 0.99567822
p_ni: 1.2e-8
p_wrong: 0.004321768
Score: 0.294
Data Source: BioPlex,STRINGDB
PDGFB
Tchem
Novelty: 0.00080876
Score: 0.905
Data Source: Reactome,STRINGDB
CD47
Tchem
Novelty: 0.00129086
Score: 0.894
Data Source: STRINGDB
CD36
Tbio
Novelty: 0.00140825
Score: 0.824
Data Source: STRINGDB
ITGA2
Tbio
Novelty: 0.0013482
Score: 0.731
Data Source: STRINGDB
ITGA9
Tbio
Novelty: 0.01488635
Score: 0.721
Data Source: STRINGDB
ITGA1
Tbio
Novelty: 0.00545805
Score: 0.714
Data Source: STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.711
Data Source: STRINGDB
ITGA6
Tbio
Novelty: 0.00217985
Score: 0.696
Data Source: STRINGDB
Publication Statistics
PubMed Score  125.93

PubMed score by year
PubTator Score  57.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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