Tbio SSX2 Protein SSX2

Protein Summary

Description

Could act as a modulator of transcription. The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q16385
• Q16404
• Q5JS26
• Q96IP7
• Q9BU88

Gene Name

• SSX2

Ensembl ID

• ENST00000336777
• ENSP00000338796
• ENSG00000241476
• ENST00000337502
• ENSP00000338561
• ENST00000596480
• ENSP00000470740
• ENSG00000268447
• ENST00000612490
• ENSP00000477922
• ENST00000616191
• ENSP00000478714

Symbol

• SSX2A
• SSX
• HD21
• CT5.2
• CT5.2A
• HOM-MEL-40

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.69
cell type or tissue	0.63
cellular component	0.44
microRNA	0.41
cell line	0.32

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Ssx2

Protein / Nucleic Acid Binding / Protein Ssx2

DTO Classes

Protein / Nucleic Acid Binding / Protein Ssx2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 557.98   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 557.98   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0