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Tbio
NPHP3
Nephrocystin-3

Protein Summary
Description
Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337331
  • ENSP00000338766
  • ENSG00000113971
  • ENST00000383282
  • ENSP00000372769

Symbol
  • KIAA2000
  • MKS7
  • NPH3
  • RHPD
  • RHPD1
  • SLSN3
  • CFAP31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
histone modification site profile
0.76
tissue sample
0.67
biological process
0.64
phenotype
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.58   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.58   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
Trafficking of myristoylated proteins to the cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
Trafficking of myristoylated proteins to the cilium
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (99)
1 – 10 of 99
UNC119
Tchem
Novelty: 0.01278653
p_int: 1
Score: 0.685
Data Source: BioPlex,STRINGDB
SNX11
Tdark
Novelty: 0.5
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
GMNN
Tbio
Novelty: 0.00563598
p_int: 0.99999989
p_ni: 1.1e-7
Data Source: BioPlex
NUP62CL
Tdark
p_int: 0.999999871
p_ni: 1.29e-7
Data Source: BioPlex
PIP
Tbio
Novelty: 0.00268794
p_int: 0.999997703
p_ni: 0.000002297
Data Source: BioPlex
CREB3
Tbio
Family: TF
Novelty: 0.00516251
p_int: 0.999980996
p_ni: 0.000019004
Score: 0.183
Data Source: BioPlex,STRINGDB
AARSD1
Tdark
Novelty: 1.1528945
p_int: 0.999920057
p_ni: 0.000079943
Data Source: BioPlex
ZNF517
Tdark
Family: TF
Novelty: 1.73333333
p_int: 0.999911451
p_ni: 0.000088549
Data Source: BioPlex
BAP1
Tbio
Family: Enzyme
Novelty: 0.00594927
p_int: 0.999736765
p_ni: 0.000263235
Data Source: BioPlex
KLHL29
Tbio
Novelty: 1.27016129
p_int: 0.999642835
p_ni: 0.000357165
Score: 0.211
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  37.58

PubMed score by year
PubTator Score  30.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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