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Tbio
CDK10
Cyclin-dependent kinase 10

Protein Summary
Description
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353379
  • ENSP00000338673
  • ENSG00000185324
  • ENST00000505473
  • ENSP00000424415
  • ENST00000617879
  • ENSP00000484357

Symbol
  • ALSAS
  • PISSLRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
kinase perturbation
0.81
histone modification site profile
0.79
protein domain
0.73
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.47   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.47   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
0
1.7
95.3
hair color
1
1
1
86.3
body height
1
1
1
69.6
cigarettes per day measurement
1
1
1
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
95.3
hair color
1
86.3
body height
1
69.6
cigarettes per day measurement
1
67.9
Protein-Protein Interactions (77)
1 – 10 of 77
TTC14
Tdark
Novelty: 0.84922113
p_int: 0.99994559
p_ni: 2.02e-7
p_wrong: 0.000054208
Data Source: BioPlex
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.994251529
p_ni: 0.005748471
Score: 0.215
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.993652986
p_ni: 0.006347014
Score: 0.178
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.960767786
p_ni: 0.039232214
Score: 0.248
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.923213027
p_ni: 0.076786973
Score: 0.17
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.893858491
p_ni: 0.106141509
Score: 0.194
Data Source: BioPlex,STRINGDB
CCNQ
Tdark
Novelty: 0.08298637
Score: 0.826
Data Source: STRINGDB
ETS2
Tbio
Family: TF
Novelty: 0.00327214
Score: 0.822
Data Source: STRINGDB
ZNF276
Tdark
Family: TF
Novelty: 0.3082638
Score: 0.738
Data Source: STRINGDB
CCNC
Tbio
Novelty: 0.00585842
Score: 0.667
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.47

PubMed score by year
PubTator Score  27.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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