SNCA
Alpha-synuclein
Protein Summary
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
- ENST00000336904
- ENSP00000338345
- ENSG00000145335
- ENST00000345009
- ENSP00000343683
- ENST00000394986
- ENSP00000378437
- ENST00000394989
- ENSP00000378440
- ENST00000394991
- ENSP00000378442
- ENST00000420646
- ENSP00000396241
- ENST00000505199
- ENSP00000421485
- ENST00000506244
- ENSP00000422238
- ENST00000508895
- ENSP00000426955
- ENST00000618500
- ENSP00000484044
- NACP
- PARK1
- PD1
- NACP
- PARK1
- PARK4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
molecular function | 1 | ||
biological term | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10610.64 (req: < 5)
Gene RIFs: 1944 (req: <= 3)
Antibodies: 2667 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10610.64 (req: >= 5)
Gene RIFs: 1944 (req: > 3)
Antibodies: 2667 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 99
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 187
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7