Protein Classes
Protein Summary
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
- ENST00000336904
- ENSP00000338345
- ENSG00000145335
- ENST00000345009
- ENSP00000343683
- ENST00000394986
- ENSP00000378437
- ENST00000394989
- ENSP00000378440
- ENST00000394991
- ENSP00000378442
- ENST00000420646
- ENSP00000396241
- ENST00000505199
- ENSP00000421485
- ENST00000506244
- ENSP00000422238
- ENST00000508895
- ENSP00000426955
- ENST00000618500
- ENSP00000484044
- NACP
- PARK1
- PD1
- NACP
- PARK1
- PARK4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
molecular function | 1 | ||
biological term | 0.99 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4602.11 (req: < 5)
Gene RIFs: 1403 (req: <= 3)
Antibodies: 2667 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4602.11 (req: >= 5)
Gene RIFs: 1403 (req: > 3)
Antibodies: 2667 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 99
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 165
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (165)
1 – 10 of 165
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (11)
Reactome (2)
KEGG (2)
PathwayCommons (3)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amyloid fiber formation | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (128)
Functions (24)
Components (29)
Processes (75)
Items per page:
10
1 – 10 of 24
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Protein-Protein Interactions (305)
1 – 10 of 305
MAN2C1
Family: Enzyme
Novelty: 0.0049976
p_int: 0.999995048
p_ni: 0.000004908
p_wrong: 4.4e-8
Score: 0.354
Data Source: BioPlex,STRINGDB
TMPRSS12
Family: Enzyme
Novelty: 0.70588235
p_int: 0.997573342
p_ni: 0.002426658
Score: 0.208
Data Source: BioPlex,STRINGDB
HK1
Family: Kinase
Novelty: 0.00089993
p_int: 0.992731345
p_ni: 0.007268655
Score: 0.254
Data Source: BioPlex,STRINGDB
DNAAF2
Novelty: 0.04657397
p_int: 0.945120326
p_ni: 0.054879649
p_wrong: 2.5e-8
Data Source: BioPlex
HCLS1
Novelty: 0.06481982
p_int: 0.915728689
p_ni: 0.006128783
p_wrong: 0.078142528
Score: 0.269
Data Source: BioPlex,STRINGDB
SERPINB13
Novelty: 0.03180119
p_int: 0.882892549
p_ni: 0.117106916
p_wrong: 5.35e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
SNCAIP
Novelty: 0.01175869
Score: 0.996
Data Source: Reactome,STRINGDB
PRKN
Family: Enzyme
Novelty: 0.00092228
Score: 0.992
Data Source: STRINGDB
PARK7
Family: Enzyme
Novelty: 0.00119335
Score: 0.99
Data Source: STRINGDB
APP
Novelty: 0.00011446
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score 4602.11
PubMed score by year
PubTator Score 4467.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAV
1-70
VTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
70-140
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
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