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Tdark
MRPL30
39S ribosomal protein L30, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. Read-through transcription also exists between this gene and the neighboring upstream lipoyltransferase 1 (LIPT1) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338148
  • ENSP00000338057
  • ENSG00000185414
  • ENST00000409841
  • ENSP00000386752

Symbol
  • MRPL28
  • RPML28
  • L28MT
  • L30MT
  • MRPL28
  • RPML28
  • MRP-L28
  • MRP-L30
  • MRPL28M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
kinase perturbation
0.81
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
small molecule perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.05   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.05   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (144)
1 – 10 of 144
MRPL51
Tdark
Novelty: 0.55263158
p_int: 0.999949933
p_ni: 0.000049934
p_wrong: 1.33e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
MRPL40
Tbio
Novelty: 0.07681266
p_int: 0.999888276
p_ni: 0.000111724
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL55
Tdark
Novelty: 0.82677165
p_int: 0.999849424
p_ni: 0.000150576
Score: 0.954
Data Source: BioPlex,STRINGDB
MRPL2
Tdark
Novelty: 1.875
p_int: 0.999803968
p_ni: 0.000196032
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL58
Tbio
Family: Enzyme
Novelty: 0.00260293
p_int: 0.99975142
p_ni: 0.00024858
Score: 0.982
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.10557056
p_int: 0.999747283
p_ni: 0.000252715
p_wrong: 2e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.10848508
p_int: 0.999663456
p_ni: 0.000150369
p_wrong: 0.000186174
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL20
Tdark
Novelty: 3.86363636
p_int: 0.99964171
p_ni: 0.00035829
Score: 0.986
Data Source: BioPlex,STRINGDB
MTERF3
Tdark
Novelty: 0.07686676
p_int: 0.999632161
p_ni: 0.000367839
Data Source: BioPlex
MRPL27
Tdark
Novelty: 0.38709677
p_int: 0.999607799
p_ni: 0.000392201
Score: 0.988
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.05

PubMed score by year
PubTator Score  0.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer