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Tdark
SPRYD4
SPRY domain-containing protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338146
  • ENSP00000338034
  • ENSG00000176422
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.79
microRNA
0.74
histone modification site profile
0.67
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
2
2
2
94.6
C-reactive protein measurement
1
1
1
90
blood metabolite measurement
3
1
4
89.7
amino acid measurement
4
1
4
89.5
protein measurement
1
1
1
85.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
2
94.6
C-reactive protein measurement
1
90
blood metabolite measurement
4
89.7
amino acid measurement
4
89.5
protein measurement
1
85.4
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (30)
1 – 10 of 30
CDC34
Tbio
Novelty: 0.00650407
p_int: 0.880552958
p_ni: 0.119446852
p_wrong: 1.9e-7
Data Source: BioPlex
CCL5
Tchem
Novelty: 0.00032607
p_int: 0.847877884
p_ni: 0.152100524
p_wrong: 0.000021592
Score: 0.252
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.812790375
p_ni: 0.187209625
Score: 0.191
Data Source: BioPlex,STRINGDB
KANSL2
Tbio
Novelty: 0.08741608
Score: 0.787
Data Source: STRINGDB
MIP
Tbio
Novelty: 0.00299543
Score: 0.729
Data Source: STRINGDB
CCNT1
Tchem
Novelty: 0.00526848
Score: 0.69
Data Source: STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
Score: 0.657
Data Source: STRINGDB
LYZL4
Tbio
Family: Enzyme
Novelty: 0.14684776
Score: 0.654
Data Source: STRINGDB
LYZL6
Tbio
Family: Enzyme
Novelty: 0.09937272
Score: 0.652
Data Source: STRINGDB
SPACA5
Tdark
Family: Enzyme
Novelty: 0.19829871
Score: 0.605
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.17

PubMed score by year
PubTator Score  1.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer