You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RTN4
Reticulon-4

Protein Classes
Protein Summary
Description
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (Pub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317610
  • ENSP00000322147
  • ENSG00000115310
  • ENST00000337526
  • ENSP00000337838
  • ENST00000357376
  • ENSP00000349944
  • ENST00000357732
  • ENSP00000350365
  • ENST00000394609
  • ENSP00000378107
  • ENST00000394611
  • ENSP00000378109
  • ENST00000404909
  • ENSP00000385650
  • ENST00000405240
  • ENSP00000384471

Symbol
  • KIAA0886
  • NOGO
  • ASY
  • NSP
  • NOGO
  • RTN-X
  • NSP-CL
  • RTN4-A
  • RTN4-C
  • RTN4-B1
  • RTN4-B2
  • NI220/250
  • Nbla00271
  • Nbla10545
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.99
co-expressed gene
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1349.07   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1349.07   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
93.9
lymphocyte count
2
2
2
70.4
mathematical ability
1
1
1
43.8
body height
1
1
1
32.5
monocyte count
1
1
1
28.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
93.9
lymphocyte count
2
70.4
mathematical ability
1
43.8
body height
1
32.5
monocyte count
1
28.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Death Receptor Signalling
Reactome
Signal Transduction
Reactome
p75 NTR receptor-mediated signalling
Reactome
p75NTR regulates axonogenesis
Name
Explore in Pharos
Explore in Source
Axonal growth inhibition (RHOA activation)
Death Receptor Signalling
Signal Transduction
p75 NTR receptor-mediated signalling
p75NTR regulates axonogenesis
Gene Ontology Terms (35)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (200)
1 – 10 of 200
RTN1
Tbio
Novelty: 0.01828064
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.678
Data Source: BioPlex,STRINGDB
ATP1B2
Tclin
Family: Transporter
Novelty: 0.02641193
p_int: 0.999999181
p_ni: 8.19e-7
Score: 0.34
Data Source: BioPlex,STRINGDB
TMEM128
Tdark
Novelty: 5.15874803
p_int: 0.999997691
p_ni: 0.000002309
Score: 0.641
Data Source: BioPlex,STRINGDB
SPOP
Tbio
Novelty: 0.00663363
p_int: 0.999994994
p_ni: 0.000004969
p_wrong: 3.7e-8
Score: 0.267
Data Source: BioPlex,STRINGDB
ARL6IP1
Tbio
Novelty: 0.07644032
p_int: 0.999994878
p_ni: 0.000005122
Score: 0.631
Data Source: BioPlex,STRINGDB
RABAC1
Tbio
Novelty: 0.01749453
p_int: 0.999960586
p_ni: 0.000015125
p_wrong: 0.000024289
Score: 0.766
Data Source: BioPlex,STRINGDB
TMEM208
Tdark
Novelty: 0.63059333
p_int: 0.99995144
p_ni: 0.000005721
p_wrong: 0.000042839
Score: 0.833
Data Source: BioPlex,STRINGDB
METTL7B
Tbio
Family: Enzyme
Novelty: 0.0873748
p_int: 0.999942679
p_ni: 0.000057192
p_wrong: 1.29e-7
Score: 0.227
Data Source: BioPlex,STRINGDB
RTN2
Tbio
Novelty: 0.05184418
p_int: 0.999906476
p_ni: 0.000093394
p_wrong: 1.3e-7
Score: 0.653
Data Source: BioPlex,STRINGDB
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.999720597
p_ni: 0.000279388
p_wrong: 1.5e-8
Score: 0.669
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1349.07

PubMed score by year
PubTator Score  1309.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: