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Tclin
LCK
Tyrosine-protein kinase Lck

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, u ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333070
  • ENSP00000328213
  • ENSG00000182866
  • ENST00000336890
  • ENSP00000337825
  • ENST00000619559
  • ENSP00000477713

Symbol
  • LSK
  • YT16
  • IMD22
  • p56lck
  • pp58lck
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
small molecule
1
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1525.2   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 1561   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1525.2   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 1561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 504
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Protein Data Bank (54)
1 – 5 of 54
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (106)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
CD28 dependent Vav1 pathway
Reactome
CTLA4 inhibitory signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (468)
1 – 10 of 468
CD4
Tclin
Novelty: 0.00001541
Score: 0.998
Data Source: Reactome,STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00019614
Score: 0.994
Data Source: Reactome,STRINGDB
CD8A
Tbio
Novelty: 0.00003113
Score: 0.994
Data Source: STRINGDB
VAV1
Tchem
Novelty: 0.00223848
Score: 0.992
Data Source: Reactome,STRINGDB
LAT
Tbio
Novelty: 0.00738606
Score: 0.991
Data Source: Reactome,STRINGDB
CD247
Tbio
Novelty: 0.00275443
Score: 0.991
Data Source: Reactome,STRINGDB
CD28
Tbio
Novelty: 0.00051946
Score: 0.99
Data Source: Reactome,STRINGDB
CTLA4
Tclin
Novelty: 0.00017405
Score: 0.989
Data Source: STRINGDB
LCP2
Tbio
Novelty: 0.00631737
Score: 0.989
Data Source: Reactome,STRINGDB
CD3E
Tclin
Novelty: 0.00541492
Score: 0.987
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1525.20

PubMed score by year
PubTator Score  844.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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