Tbio DCX Neuronal migration protein doublecortin

Protein Summary

Description

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• O43602
• A6NFY6
• A9Z1V8
• D3DUY8
• D3DUY9
• D3DUZ0
• O43911
• Q5JYZ5

Gene Name

• DCX

Ensembl ID

• ENST00000358070
• ENSP00000350776
• ENSG00000077279
• ENST00000371993
• ENSP00000361061
• ENST00000488120
• ENSP00000419861
• ENST00000496551
• ENSP00000490448
• ENST00000635795
• ENSP00000489635

Symbol

• DBCN
• LISX
• DC
• DBCN
• LISX
• SCLH
• XLIS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.97
hub protein	0.79
molecular function	0.76
transcription factor perturbation	0.68
biological term	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.59   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 657   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.59   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (131)

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1 – 10 of 131

• See Interactions on String-DB

NMNAT3

Tbio

Family:  Enzyme

Novelty:  0.03261313

p_int:  0.999995348

p_ni:  2.45e-7

p_wrong:  0.000004408

Score:  0.543

Data Source:  BioPlex,STRINGDB

DCLK1

Tchem

Family:  Kinase

Novelty:  0.0064994

p_int:  0.999989667

p_ni:  1e-9

p_wrong:  0.000010332

Score:  0.884

Data Source:  BioPlex,STRINGDB

DIS3

Tbio

Family:  Enzyme

Novelty:  0.00961238

p_int:  0.999268835

p_ni:  0.000731165

Score:  0.211

Data Source:  BioPlex,STRINGDB

NUFIP1

Tbio

Novelty:  0.11726869

p_int:  0.994650398

p_ni:  0.005349599

p_wrong:  4e-9

Data Source:  BioPlex

DGUOK

Tbio

Family:  Kinase

Novelty:  0.00897987

p_int:  0.99406121

p_ni:  0.005938789

p_wrong:  1e-9

Data Source:  BioPlex

HAX1

Tbio

Novelty:  0.00749205

p_int:  0.994005006

p_ni:  0.005994988

p_wrong:  6e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

NDUFA10

Tclin

Family:  Enzyme

Novelty:  0.06260343

p_int:  0.983344425

p_ni:  0.016655574

p_wrong:  1e-9

Data Source:  BioPlex

LGALS9C

Tdark

Novelty:  0.29969898

p_int:  0.97509093

p_ni:  0.024909054

p_wrong:  1.6e-8

Data Source:  BioPlex

RGL4

Tdark

Novelty:  0.29339149

p_int:  0.972499343

p_ni:  0.027498235

p_wrong:  0.000002422

Score:  0.359

Data Source:  BioPlex,STRINGDB

DPF3

Tbio

Family:  Epigenetic

Novelty:  0.069151

p_int:  0.970168712

p_ni:  0.02983126

p_wrong:  2.7e-8

Score:  0.194

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

PathwayCommons (1)

Axon guidance (R-HSA-422475)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	L1CAM interactions	100 targets	R-HSA-373760
Reactome	Neurofascin interactions	7 targets	R-HSA-447043

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
L1CAM interactions	100 targets	R-HSA-373760
Neurofascin interactions	7 targets	R-HSA-447043

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (2)

Components (6)

Processes (7)

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1 – 2 of 2

GO Term	Evidence	Assigned by
microtubule binding	Inferred from Direct Assay (IDA)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell projection
Chromosomal rearrangement
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Disease mutation
Epilepsy

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	doublecortin		706556
Mouse	doublecortin	MGI:1277171	13193
Rat	doublecortin	RGD:620670	84394
Dog	doublecortin	VGNC:54132	612950
Horse	doublecortin		100058909

Species	Name	OMA	EggNOG	Inparanoid
Macaque	doublecortin
Mouse	doublecortin
Rat	doublecortin
Dog	doublecortin
Horse	doublecortin

Publication Statistics

PubMed Score 1068.59

PubMed score by year

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PubTator Score 346.45

PubTator score by year

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Related Publications

Text Mined References (85)

GeneRif Annotations (46)

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10

0 of 0

PMID	Year	Title