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Tchem
NLRP3
NACHT, LRR and PYD domains-containing protein 3

Protein Summary
Description
As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336119
  • ENSP00000337383
  • ENSG00000162711
  • ENST00000348069
  • ENSP00000294752
  • ENST00000366496
  • ENSP00000355452
  • ENST00000366497
  • ENSP00000355453
  • ENST00000391827
  • ENSP00000375703
  • ENST00000391828
  • ENSP00000375704
  • ENST00000474792
  • ENSP00000493937
  • ENST00000643234
  • ENSP00000493674

Symbol
  • C1orf7
  • CIAS1
  • NALP3
  • PYPAF1
  • AII
  • AVP
  • FCU
  • MWS
  • FCAS
  • KEFH
  • CIAS1
  • FCAS1
  • NALP3
  • C1orf7
  • CLR1.1
  • DFNA34
  • PYPAF1
  • AGTAVPRL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
protein domain
0.85
molecular function
0.81
phenotype
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2624.76   (req: < 5)
Gene RIFs: 531   (req: <= 3)
Antibodies: 731   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2624.76   (req: >= 5)
Gene RIFs: 531   (req: > 3)
Antibodies: 731   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
3
5
99.3
fibrinogen measurement
5
3
5
96.4
myeloid white cell count
2
2
2
88.9
neutrophil count
3
2
3
88.7
leukocyte count
2
3
3
70.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
99.3
fibrinogen measurement
5
96.4
myeloid white cell count
2
88.9
neutrophil count
3
88.7
leukocyte count
3
70.6
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Deubiquitination
Immune System
Inflammasomes
Innate Immune System
Metabolism of proteins
Gene Ontology Terms (45)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (247)
1 – 10 of 247
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.997
Data Source: Reactome,STRINGDB
PYCARD
Tbio
Novelty: 0.00719985
Score: 0.996
Data Source: Reactome,STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.988
Data Source: STRINGDB
TXNIP
Tbio
Novelty: 0.00216952
Score: 0.988
Data Source: Reactome,STRINGDB
CARD8
Tbio
Family: Enzyme
Novelty: 0.0146799
Score: 0.988
Data Source: STRINGDB
AIM2
Tbio
Novelty: 0.00360474
Score: 0.986
Data Source: STRINGDB
NLRC4
Tbio
Novelty: 0.0032237
Score: 0.98
Data Source: STRINGDB
DHX33
Tbio
Family: Enzyme
Novelty: 0.07473852
Score: 0.977
Data Source: STRINGDB
CASP5
Tchem
Family: Enzyme
Novelty: 0.00734661
Score: 0.976
Data Source: STRINGDB
NEK7
Tchem
Family: Kinase
Novelty: 0.02675561
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  2624.76

PubMed score by year
PubTator Score  1995.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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