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Tbio
CDCA4
Cell division cycle-associated protein 4

Protein Summary
Description
May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity). This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336219
  • ENSP00000337226
  • ENSG00000170779
  • ENST00000392590
  • ENSP00000376369

Symbol
  • HEPP
  • HEPP
  • SEI-3/HEPP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor binding site profile
0.84
disease perturbation
0.83
transcription factor perturbation
0.8
microRNA
0.79


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cell division cycle associated 4
708068
Mouse
MGI:1919213
71963
Rat
RGD:1563593
500727
Dog
cell division cycle associated 4
VGNC:39014
612703
Horse
cell division cycle associated 4
VGNC:16310
100062431
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cell division cycle associated 4
Mouse
Rat
Dog
cell division cycle associated 4
Horse
cell division cycle associated 4
Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (51)
1 – 10 of 51
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 1
Score: 0.54
Data Source: BioPlex,STRINGDB
PPP2R2C
Tbio
Family: Enzyme
Novelty: 0.05453128
p_int: 0.999999536
p_ni: 3.71e-7
p_wrong: 9.3e-8
Score: 0.707
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
p_int: 0.999823102
p_ni: 0.000176898
Score: 0.638
Data Source: BioPlex,STRINGDB
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
p_int: 0.998251601
p_ni: 0.001748399
Score: 0.565
Data Source: BioPlex,STRINGDB
BDH2
Tbio
Family: Enzyme
Novelty: 0.04118875
p_int: 0.990494111
p_ni: 0.009505889
Score: 0.187
Data Source: BioPlex,STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01110899
p_int: 0.978261419
p_ni: 0.021738563
p_wrong: 1.8e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
CPNE7
Tbio
Novelty: 0.0748235
p_int: 0.976763431
p_ni: 0.023231434
p_wrong: 0.000005135
Score: 0.158
Data Source: BioPlex,STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.967926978
p_ni: 0.032054325
p_wrong: 0.000018698
Score: 0.708
Data Source: BioPlex,STRINGDB
SERTAD4
Tdark
Novelty: 0.70786986
Score: 0.804
Data Source: STRINGDB
SERTAD1
Tbio
Novelty: 0.04704547
Score: 0.804
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.26

PubMed score by year
PubTator Score  70.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer