Tchem MEN1 Menin

Protein Classes

DTO Classes

Calumenin / Sarcalumenin / Meningioma Cell Line / Meningioma Cell / Meningioma / Meningocele / Meningitis

Protein Summary

Description

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O00255
• A5HBC6
• A5HBC7
• A5HBC8
• A5HBC9
• A5HBD0
• A5HBD1
• A5HBD2
• O00632
• Q9BUF0
• Q9BUK2

Gene Name

• MEN1

Ensembl ID

• ENST00000312049
• ENSP00000308975
• ENSG00000133895
• ENST00000315422
• ENSP00000323747
• ENST00000337652
• ENSP00000337088
• ENST00000377313
• ENSP00000366530
• ENST00000377321
• ENSP00000366538
• ENST00000377326
• ENSP00000366543
• ENST00000394374
• ENSP00000377899
• ENST00000394376
• ENSP00000377901

Symbol

• SCG2
• MEAI
• SCG2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.96
hub protein	0.94
disease perturbation	0.83
phenotype	0.79

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1916.96   (req: < 5)

Gene RIFs: 207   (req: <= 3)

Antibodies: 479   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1916.96   (req: >= 5)

Gene RIFs: 207   (req: > 3)

Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 48

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (48)

Explore Active Ligands

1 – 10 of 48

CHEMBL2314571,CHEMBL2314569

MEN1Tchem

Ki: 7.57

CHEMBL2314834

MEN1Tchem

Ki: 7.37

CHEMBL2315084

MEN1Tchem

Ki: 6.71

CHEMBL2314819

MEN1Tchem

Ki: 8.33

CHEMBL2314830

MEN1Tchem

Ki: 7.76

CHEMBL3696180

MEN1Tchem

IC50: 6.19

CHEMBL2314833

MEN1Tchem

Ki: 8.16

CHEMBL2314818

MEN1Tchem

Ki: 6.91

CHEMBL3126198

MEN1Tchem

Kd: 7.07

CHEMBL3124953

MEN1Tchem

Kd: 6.02

Protein Data Bank (29)

1 – 5 of 29

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (22)

Reactome (19)

KEGG (2)

PathwayCommons (1)

Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

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Items per page:

5

1 – 5 of 19

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Deactivation of the beta-catenin transactivating complex	42 targets	R-HSA-3769402
Reactome	Formation of the beta-catenin:TCF transactivating complex	61 targets	R-HSA-201722
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Deactivation of the beta-catenin transactivating complex	42 targets	R-HSA-3769402
Formation of the beta-catenin:TCF transactivating complex	61 targets	R-HSA-201722
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of proteins	2050 targets	R-HSA-392499

Gene Ontology Terms (55)

Functions (8)

Components (12)

Processes (35)

Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
double-stranded DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
four-way junction DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein binding, bridging	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
Y-form DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein N-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
R-SMAD binding	Inferred from Physical Interaction (IPI)	BHF-UCL
chromatin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (324)

Explore Interacting Targets

1 – 10 of 324

• See Interactions on String-DB

CD226

Tbio

Novelty: 0.00453644

p_int: 0.958818487

p_ni: 0.041181513

Data Source: BioPlex

RBBP5

Tbio

Novelty: 0.0339304

Score: 0.989

Data Source: STRINGDB

ASH2L

Tbio

Family: Enzyme

Novelty: 0.02441135

Score: 0.987

Data Source: STRINGDB

WDR5

Tchem

Novelty: 0.00689807

Score: 0.98

Data Source: STRINGDB

SMAD3

Tbio

Family: TF

Novelty: 0.00058288

Score: 0.979

Data Source: Reactome,STRINGDB

KMT2D

Tbio

Family: Epigenetic

Novelty: 0.00631634

Score: 0.976

Data Source: STRINGDB

CTNNB1

Tchem

Novelty: 0.00008951

Score: 0.975

Data Source: Reactome,STRINGDB

KMT2A

Tchem

Family: Epigenetic

Novelty: 0.0006021

Score: 0.969

Data Source: STRINGDB

JUND

Tbio

Family: TF

Novelty: 0.00337776

Score: 0.957

Data Source: STRINGDB

HDAC1

Tclin

Family: Epigenetic

Novelty: 0.00083441

Score: 0.954

Data Source: STRINGDB

Publication Statistics

PubMed Score  1916.96

PubMed score by year

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PubTator Score  1599.75

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPD

1-70

PPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHI

70-140

QSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNED

140-210

RRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLER

210-280

YPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTA

280-350

TVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLR

350-420

FYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRR

420-490

ESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQS

490-560

EKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL

560-615

MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGWSPVGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Chromatin regulator
Complete proteome
Disease mutation
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome