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Tchem
UNC119
Protein unc-119 homolog A

Protein Classes
Protein Summary
Description
Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A. This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor sy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301032
  • ENSP00000301032
  • ENSG00000109103
  • ENST00000335765
  • ENSP00000337040

Symbol
  • RG4
  • HRG4
  • POC7
  • IMD13
  • POC7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
small molecule perturbation
0.78
biological process
0.74
tissue sample
0.68
cell type or tissue
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.62   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 268.62   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
squarunkin A
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-119 lipid binding chaperone
VGNC:9763
455028
Macaque
unc-119 lipid binding chaperone
716064
Mouse
MGI:1328357
22248
Rat
RGD:3942
29402
Dog
unc-119 lipid binding chaperone
VGNC:48133
491169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-119 lipid binding chaperone
Macaque
unc-119 lipid binding chaperone
Mouse
Rat
Dog
unc-119 lipid binding chaperone
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13432-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (114)
1 – 10 of 114
NPHP3
Tbio
Novelty: 0.02857926
p_int: 1
Score: 0.685
Data Source: BioPlex,STRINGDB
PRKG2
Tchem
Family: Kinase
Novelty: 0.0138455
p_int: 1
Score: 0.313
Data Source: BioPlex,STRINGDB
PDE9A
Tchem
Family: Enzyme
Novelty: 0.01862532
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.329
Data Source: BioPlex,STRINGDB
PDE8A
Tclin
Family: Enzyme
Novelty: 0.04254335
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.271
Data Source: BioPlex,STRINGDB
FAM13A
Tbio
Novelty: 0.02851485
p_int: 0.999999992
p_ni: 8e-9
Score: 0.232
Data Source: BioPlex,STRINGDB
RNF34
Tbio
Family: Enzyme
Novelty: 0.04365307
p_int: 0.99999999
p_ni: 1e-8
Score: 0.313
Data Source: BioPlex,STRINGDB
LIMK2
Tchem
Family: Kinase
Novelty: 0.0153308
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
C5orf30
Tdark
Novelty: 0.2072045
p_int: 0.999999955
p_ni: 4.4e-8
p_wrong: 2e-9
Score: 0.738
Data Source: BioPlex,STRINGDB
LZTS1
Tbio
Novelty: 0.02747372
p_int: 0.99999991
p_ni: 8.1e-8
p_wrong: 9e-9
Score: 0.818
Data Source: BioPlex,STRINGDB
LZTS2
Tbio
Novelty: 0.09515452
p_int: 0.99999964
p_ni: 3.6e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  268.62

PubMed score by year
PubTator Score  16.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer