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Tbio
SYNM
Synemin

Protein Summary
Description
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336292
  • ENSP00000336775
  • ENSG00000182253

Symbol
  • DMN
  • KIAA0353
  • SYN
  • DMN
  • SYN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
transcription factor binding site profile
0.69
PubMedID
0.68
small molecule perturbation
0.61
cell line
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.24   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.24   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synemin
VGNC:1615
467773
Macaque
synemin
717194
Mouse
MGI:2661187
233335
Rat
RGD:727872
308709
Dog
synemin
VGNC:53243
479024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synemin
Macaque
synemin
Mouse
Rat
Dog
synemin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15061-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (35)
1 – 10 of 35
DNAJB4
Tbio
Novelty: 0.03467352
p_int: 0.999999879
p_ni: 1.19e-7
p_wrong: 2e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.999991051
p_ni: 0.000008947
p_wrong: 2e-9
Score: 0.857
Data Source: BioPlex,STRINGDB
CT55
Tdark
Novelty: 0.20854606
p_int: 0.999947854
p_ni: 0.000052133
p_wrong: 1.3e-8
Score: 0.228
Data Source: BioPlex,STRINGDB
LHX4
Tbio
Family: TF
Novelty: 0.02047732
Score: 0.756
Data Source: STRINGDB
LHX3
Tbio
Family: TF
Novelty: 0.00784158
Score: 0.744
Data Source: STRINGDB
DTNA
Tbio
Novelty: 0.01165754
Score: 0.724
Data Source: STRINGDB
PLEC
Tbio
Novelty: 0.00223244
Score: 0.62
Data Source: STRINGDB
CMYA5
Tbio
Novelty: 0.05675889
Score: 0.616
Data Source: STRINGDB
TTN
Tbio
Family: Kinase
Novelty: 0.00040356
Score: 0.604
Data Source: STRINGDB
FLNC
Tbio
Novelty: 0.00463205
Score: 0.592
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.24

PubMed score by year
PubTator Score  3435.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer