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Tbio
KIR2DL1
Killer cell immunoglobulin-like receptor 2DL1

Protein Classes
Protein Summary
Description
Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and inst ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291633
  • ENSP00000291633
  • ENSG00000125498
  • ENST00000611611
  • ENSP00000478232
  • ENSG00000278738
  • ENST00000615920
  • ENSP00000482120
  • ENSG00000273794
  • ENST00000617376
  • ENSP00000484559
  • ENSG00000278821
  • ENST00000618563
  • ENSP00000484361
  • ENSG00000276625
  • ENST00000620449
  • ENSP00000478263
  • ENSG00000277833
  • ENST00000622463
  • ENSP00000479363
  • ENSG00000278495

Symbol
  • CD158A
  • NKAT1
  • NKAT
  • NKAT1
  • p58.1
  • CD158A
  • KIR221
  • NKAT-1
  • KIR-K64
  • KIR2DL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
1
cell type or tissue
0.93
disease
0.88
cell line
0.63
microRNA
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.85   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 650   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.85   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (170)
1 – 10 of 170
KIR2DL2
Tdark
p_int: 0.999999996
p_wrong: 4e-9
Data Source: BioPlex
KIR2DS3
Tdark
p_int: 0.999999993
p_wrong: 7e-9
Data Source: BioPlex
KIR3DL1
Tbio
Novelty: 0.00319964
p_int: 0.999999979
p_ni: 1.7e-8
p_wrong: 3e-9
Score: 0.864
Data Source: BioPlex,STRINGDB
FAM114A2
Tdark
Novelty: 0.75
p_int: 0.999999972
p_ni: 2.8e-8
Data Source: BioPlex
RHBDF2
Tbio
Family: Enzyme
Novelty: 0.02152024
p_int: 0.999995596
p_ni: 0.000004404
Data Source: BioPlex
FLVCR1
Tbio
Novelty: 0.02580936
p_int: 0.999885941
p_ni: 0.000114059
Data Source: BioPlex
PLCH1
Tbio
Family: Enzyme
Novelty: 0.20668236
p_int: 0.999605689
p_ni: 0.000392744
p_wrong: 0.000001567
Data Source: BioPlex
SLC4A7
Tbio
Family: Transporter
Novelty: 0.01401859
p_int: 0.999396942
p_ni: 0.000603058
Data Source: BioPlex
STX6
Tbio
Novelty: 0.01577464
p_int: 0.999203973
p_ni: 0.000676236
p_wrong: 0.000119791
Data Source: BioPlex
GOSR1
Tbio
Novelty: 0.04353116
p_int: 0.999131105
p_ni: 0.000867019
p_wrong: 0.000001877
Data Source: BioPlex
Publication Statistics
PubMed Score  320.85

PubMed score by year
PubTator Score  112.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSLLVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGMFNDTL
1-70
RLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQPGPTVL
70-140
AGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWS
140-210
KSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQE
210-280
SAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP
280-348
MSLLVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQPGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP