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Tchem
LIMK1
LIM domain kinase 1

Protein Summary
Description
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336180
  • ENSP00000336740
  • ENSG00000106683
  • ENST00000435201
  • ENSP00000414606
  • ENST00000538333
  • ENSP00000444452

Symbol
  • LIMK
  • LIMK
  • LIMK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.91
kinase
0.86
protein domain
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.97   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 887   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.97   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 887   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (54)
1 – 10 of 54
CHEMBL3218297,CHEMBL3218011
chemical structure image
voruciclib
chemical structure image
CHEMBL3356433
chemical structure image
CHEMBL2070619
chemical structure image
CHEMBL3586447
chemical structure image
CHEMBL2070615
chemical structure image
CHEMBL570126
chemical structure image
compound 30 [PMID: 22902653]
chemical structure image
CHEMBL3613610
chemical structure image
CHEMBL3613620
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.6
54.4
monocyte count
1
1
1
45.6
1
1
0
1.5
5.7
1
1
0
1.5
5.7
1
1
0
1.5
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
54.4
monocyte count
1
45.6
0
1.5
5.7
0
1.5
5.7
0
1.5
5.7
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (141)
1 – 10 of 141
CFL1
Tbio
Novelty: 0.00071544
Score: 0.997
Data Source: Reactome,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.979
Data Source: Reactome,STRINGDB
CFL2
Tbio
Novelty: 0.01563343
Score: 0.977
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.976
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.967
Data Source: Reactome,STRINGDB
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
Score: 0.96
Data Source: Reactome,STRINGDB
ROCK1
Tclin
Family: Kinase
Novelty: 0.00156045
Score: 0.96
Data Source: Reactome,STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.959
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.958
Data Source: Reactome,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.958
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  291.97

PubMed score by year
PubTator Score  170.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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