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Tbio
CDKN3
Cyclin-dependent kinase inhibitor 3

Protein Summary
Description
May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner. The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.81
gene perturbation
0.76
small molecule perturbation
0.7
PubMedID
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.9   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 459   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.9   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
62.4
red blood cell distribution width
1
1
1
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
62.4
red blood cell distribution width
1
49.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (298)
1 – 10 of 298
BRCA1
Tchem
Novelty: 0.00011146
p_int: 0.999999977
p_ni: 2.2e-8
p_wrong: 1e-9
Score: 0.554
Data Source: BioPlex,STRINGDB
R3HCC1L
Tbio
Novelty: 0.00654375
p_int: 0.999999964
p_ni: 2.8e-8
p_wrong: 9e-9
Data Source: BioPlex
WWC1
Tbio
Novelty: 0.00905646
p_int: 0.999996482
p_ni: 0.000003227
p_wrong: 2.9e-7
Data Source: BioPlex
BAIAP2L1
Tbio
Novelty: 0.06381886
p_int: 0.999951337
p_ni: 0.000048663
Data Source: BioPlex
CST8
Tbio
Novelty: 0.02316886
p_int: 0.999944153
p_ni: 0.00005552
p_wrong: 3.27e-7
Data Source: BioPlex
JMY
Tbio
Novelty: 0.01850088
p_int: 0.999805282
p_ni: 0.000067849
p_wrong: 0.00012687
Data Source: BioPlex
C18orf25
Tdark
Novelty: 0.67505268
p_int: 0.996946635
p_ni: 0.003053353
p_wrong: 1.1e-8
Data Source: BioPlex
NOL11
Tbio
Novelty: 0.47253767
p_int: 0.978300193
p_ni: 0.021699807
Data Source: BioPlex
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.942669729
p_ni: 8.7e-8
p_wrong: 0.057330183
Score: 0.984
Data Source: BioPlex,STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
p_int: 0.897356315
p_ni: 0.102643685
Score: 0.447
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  569.90

PubMed score by year
PubTator Score  136.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer