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Tbio
SF3B1
Splicing factor 3B subunit 1

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335508
  • ENSP00000335321
  • ENSG00000115524
  • ENST00000409915
  • ENSP00000428820
  • ENST00000414963
  • ENSP00000402997

Symbol
  • SAP155
  • MDS
  • PRP10
  • Hsh155
  • PRPF10
  • SAP155
  • SF3b155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase perturbation
0.99
transcription factor perturbation
0.88
drug perturbation
0.87
protein complex
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.21   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.21   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
2
1
1.1
71.4
self reported educational attainment
1
1
1
26.8
intelligence
1
1
1
26.8
1
1
0
1.1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
71.4
self reported educational attainment
1
26.8
intelligence
1
26.8
0
1.1
3.5
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Positive epigenetic regulation of rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Metabolism of RNA
Positive epigenetic regulation of rRNA expression
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (439)
1 – 10 of 439
CCDC97
Tdark
Novelty: 2.36351796
p_int: 0.99988672
p_ni: 0.00011328
Score: 0.983
Data Source: BioPlex,STRINGDB
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.02989472
p_int: 0.999613728
p_ni: 0.000386272
Score: 0.999
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.998990018
p_ni: 0.001009982
Score: 0.997
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.998226869
p_ni: 0.001773131
Score: 0.986
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.994863166
p_ni: 0.005136834
Data Source: BioPlex
SNRPA1
Tbio
Novelty: 0.01232044
p_int: 0.992645829
p_ni: 0.007354171
Score: 0.999
Data Source: BioPlex,STRINGDB
ZRSR2
Tbio
Novelty: 0.03449891
p_int: 0.98966913
p_ni: 0.01033087
Score: 0.991
Data Source: BioPlex,STRINGDB
SNRPB2
Tbio
Novelty: 0.17219587
p_int: 0.989279919
p_ni: 0.010720081
Score: 0.999
Data Source: BioPlex,STRINGDB
SNRPB
Tbio
Novelty: 0.01503535
p_int: 0.970042174
p_ni: 0.029957826
Score: 0.998
Data Source: BioPlex,STRINGDB
ZCRB1
Tdark
Novelty: 0.37592387
p_int: 0.958288655
p_ni: 0.041711345
Score: 0.968
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  88.21

PubMed score by year
PubTator Score  222.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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