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Tbio
BCDIN3D
Pre-miRNA 5'-monophosphate methyltransferase

Protein Summary
Description
O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs. This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs thro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333924
  • ENSP00000335201
  • ENSG00000186666
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.68
cell type or tissue
0.64
tissue sample
0.57
biological process
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.73   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.73   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
MicroRNA (miRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
MicroRNA (miRNA) biogenesis
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (33)
1 – 10 of 33
SIX2
Tbio
Family: TF
Novelty: 0.00257137
p_int: 0.999747062
p_ni: 0.000252907
p_wrong: 3.1e-8
Score: 0.277
Data Source: BioPlex,STRINGDB
ZC3H10
Tbio
Novelty: 0.70909091
Score: 0.77
Data Source: STRINGDB
FAIM2
Tbio
Novelty: 0.00395554
Score: 0.679
Data Source: STRINGDB
KCTD15
Tbio
Novelty: 0.08567174
Score: 0.676
Data Source: STRINGDB
SEC16B
Tbio
Novelty: 0.06732683
Score: 0.67
Data Source: STRINGDB
TMEM18
Tbio
Novelty: 0.03157537
Score: 0.669
Data Source: STRINGDB
GNPDA2
Tbio
Family: Enzyme
Novelty: 0.04593829
Score: 0.668
Data Source: STRINGDB
SH2B1
Tbio
Novelty: 0.02297011
Score: 0.663
Data Source: STRINGDB
MTCH2
Tbio
Novelty: 0.01969448
Score: 0.647
Data Source: STRINGDB
RNMT
Tbio
Family: Enzyme
Novelty: 0.00905808
Score: 0.588
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.73

PubMed score by year
PubTator Score  4.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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