You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
F3
Tissue factor

Protein Summary
Description
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the co ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334047
  • ENSP00000334145
  • ENSG00000117525
  • ENST00000370207
  • ENSP00000359226

Symbol
  • TF
  • TFA
  • CD142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
small molecule perturbation
0.94
chemical
0.89
biological process
0.82
biological term
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14444.53   (req: < 5)
Gene RIFs: 530   (req: <= 3)
Antibodies: 863   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14444.53   (req: >= 5)
Gene RIFs: 530   (req: > 3)
Antibodies: 863   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 112
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coagulation factor III, tissue factor
VGNC:9992
457038
Mouse
MGI:88381
14066
Rat
RGD:2587
25584
Dog
coagulation factor III, tissue factor
VGNC:54021
490153
Horse
coagulation factor III, tissue factor
VGNC:50832
100058506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coagulation factor III, tissue factor
Mouse
Rat
Dog
coagulation factor III, tissue factor
Horse
coagulation factor III, tissue factor
Protein Structure (48 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13726-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 48
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Extrinsic Pathway of Fibrin Clot Formation (R-HSA-140834)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extrinsic Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Extrinsic Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (175)
1 – 10 of 175
TM9SF4
Tbio
Novelty: 0.10441964
p_int: 0.828121708
p_ni: 0.171878292
Score: 0.513
Data Source: BioPlex,STRINGDB
DAD1
Tbio
Family: Enzyme
Novelty: 0.00653242
p_int: 0.754089883
p_ni: 0.245909982
p_wrong: 1.35e-7
Score: 0.269
Data Source: BioPlex,STRINGDB
F7
Tchem
Family: Enzyme
Novelty: 0.0002521
Score: 0.999
Data Source: Reactome,STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.993
Data Source: STRINGDB
F10
Tclin
Family: Enzyme
Novelty: 0.00063008
Score: 0.992
Data Source: Reactome,STRINGDB
TFPI
Tchem
Novelty: 0.00060355
Score: 0.991
Data Source: Reactome,STRINGDB
F9
Tchem
Family: Enzyme
Novelty: 0.00032127
Score: 0.986
Data Source: Reactome,STRINGDB
F5
Tbio
Novelty: 0.00161772
Score: 0.956
Data Source: STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.923
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  14444.53

PubMed score by year
PubTator Score  2592.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: