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Tbio
EXOC7
Exocyst complex component 7

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332065
  • ENSP00000333806
  • ENSG00000182473
  • ENST00000335146
  • ENSP00000334100
  • ENST00000411744
  • ENSP00000404322
  • ENST00000589210
  • ENSP00000468404
  • ENST00000634349
  • ENSP00000489266

Symbol
  • EXO70
  • KIAA1067
  • BLOM4
  • EX070
  • EXO70
  • EXOC1
  • 2-5-3p
  • Exo70p
  • YJL085W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
histone modification site profile
0.91
kinase perturbation
0.81
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.16   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.16   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
29.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
29.1
Pathways (79)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (218)
1 – 10 of 218
EXOC6
Tbio
Novelty: 0.01886811
p_int: 0.999999733
p_ni: 2.67e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOC8
Tbio
Novelty: 0.03090842
p_int: 0.999996301
p_ni: 0.000003699
Score: 0.999
Data Source: BioPlex,STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
p_int: 0.999972277
p_ni: 0.000027723
Score: 0.452
Data Source: BioPlex,STRINGDB
EXOC3
Tbio
Novelty: 0.01051955
p_int: 0.999886159
p_ni: 0.000113841
Score: 0.999
Data Source: BioPlex,STRINGDB
COG6
Tbio
Novelty: 0.02874093
p_int: 0.999631336
p_ni: 0.000368664
Score: 0.819
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999337639
p_ni: 0.000662361
Score: 0.25
Data Source: BioPlex,STRINGDB
DSN1
Tbio
Novelty: 0.05336903
p_int: 0.998981919
p_ni: 0.001018081
Data Source: BioPlex
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.995421507
p_ni: 0.004578492
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
STX11
Tbio
Novelty: 0.01670743
p_int: 0.985917049
p_ni: 0.014082944
p_wrong: 8e-9
Score: 0.457
Data Source: BioPlex,STRINGDB
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.985136382
p_ni: 0.014863617
Data Source: BioPlex
Publication Statistics
PubMed Score  126.16

PubMed score by year
PubTator Score  27.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer