You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NDEL1
Nuclear distribution protein nudE-like 1

Protein Summary
Description
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334527
  • ENSP00000333982
  • ENSG00000166579
  • ENST00000402554
  • ENSP00000384963

Symbol
  • EOPA
  • MITAP1
  • NUDEL
  • EOPA
  • NDE2
  • NUDEL
  • MITAP1
  • NDE1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.95
biological process
0.94
kinase
0.88
cellular component
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.03   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 430   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.03   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudE neurodevelopment protein 1 like 1
VGNC:9471
455091
Macaque
nudE neurodevelopment protein 1 like 1
721973
Mouse
MGI:1932915
83431
Rat
RGD:621235
170845
Dog
nudE neurodevelopment protein 1 like 1
VGNC:43672
489495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudE neurodevelopment protein 1 like 1
Macaque
nudE neurodevelopment protein 1 like 1
Mouse
Rat
Dog
nudE neurodevelopment protein 1 like 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9GZM8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (46)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (215)
1 – 10 of 215
DIXDC1
Tbio
Novelty: 0.05901474
p_int: 1
Score: 0.636
Data Source: BioPlex,STRINGDB
CCSER1
Tbio
Novelty: 0.20244518
p_int: 1
Score: 0.617
Data Source: BioPlex,STRINGDB
CCSER2
Tdark
Novelty: 0.4314872
p_int: 0.999999999
p_ni: 1e-9
Score: 0.407
Data Source: BioPlex,STRINGDB
KIF20B
Tbio
Novelty: 0.0465712
p_int: 0.999999842
p_ni: 1.58e-7
Score: 0.2
Data Source: BioPlex,STRINGDB
GRIPAP1
Tbio
Novelty: 0.09814766
p_int: 0.999999834
p_ni: 1.66e-7
Score: 0.391
Data Source: BioPlex,STRINGDB
CEP135
Tbio
Novelty: 0.03507768
p_int: 0.999999588
p_ni: 4.11e-7
Score: 0.37
Data Source: BioPlex,STRINGDB
ANKRD26
Tbio
Novelty: 0.02266046
p_int: 0.999999549
p_ni: 4.5e-7
p_wrong: 1e-9
Score: 0.287
Data Source: BioPlex,STRINGDB
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.999999283
p_ni: 7.17e-7
Score: 0.934
Data Source: BioPlex,STRINGDB
NDE1
Tbio
Novelty: 0.00567438
p_int: 0.999998191
p_ni: 0.000001808
Score: 0.955
Data Source: BioPlex,STRINGDB
NUP54
Tbio
Novelty: 0.08155008
p_int: 0.999991173
p_ni: 0.000008827
Data Source: BioPlex
Publication Statistics
PubMed Score  77.03

PubMed score by year
PubTator Score  63.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: