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Tbio
NXPH4
Neurexophilin-4

Protein Summary
Description
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349394
  • ENSP00000333593
  • ENSG00000182379

Symbol
  • NPH4
  • NPH4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
disease perturbation
0.68
tissue sample
0.68
transcription factor
0.62
small molecule perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.95   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.95   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
59.4
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
50.5
4
1
1
1.2
19.1
intelligence
1
1
1
4.3
self reported educational attainment
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
59.4
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
50.5
1
1.2
19.1
intelligence
1
4.3
self reported educational attainment
1
4.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurexophilin 4
VGNC:5515
100608585
Mouse
MGI:1336197
104080
Rat
RGD:628723
59316
Horse
neurexophilin 4 [Source:HGNC Symbol;Acc:HGNC:8078]
Cow
neurexophilin 4
VGNC:32383
539535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurexophilin 4
Mouse
Rat
Horse
neurexophilin 4 [Source:HGNC Symbol;Acc:HGNC:8078]
Cow
neurexophilin 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95158-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (28)
1 – 10 of 28
LY86
Tbio
Novelty: 0.00314575
p_int: 0.934121831
p_ni: 0.064408987
p_wrong: 0.001469182
Data Source: BioPlex
CST9L
Tdark
Novelty: 0.21941207
p_int: 0.928643529
p_ni: 0.071355397
p_wrong: 0.000001074
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.916000382
p_ni: 0.075113277
p_wrong: 0.008886341
Data Source: BioPlex
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.80043958
p_ni: 0.152113283
p_wrong: 0.047447137
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.758228435
p_ni: 0.219649545
p_wrong: 0.022122019
Score: 0.188
Data Source: BioPlex,STRINGDB
NRXN1
Tbio
Novelty: 0.00454659
Score: 0.761
Data Source: STRINGDB
NRXN1
Tbio
Novelty: 0.00454659
Score: 0.761
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.715
Data Source: STRINGDB
P4HTM
Tchem
Family: Enzyme
Novelty: 0.00582577
Score: 0.652
Data Source: STRINGDB
NXPE4
Tdark
Novelty: 0.77136026
Score: 0.622
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.95

PubMed score by year
PubTator Score  5.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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