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Tbio
PLPBP
Pyridoxal phosphate homeostasis protein

Protein Summary
Description
Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. This gene encodes a pyridoxal 5'-phosphate binding protein involved in the homeostatic regulation of intracellular pyridoxal 5'-phosphate. This gene has a tumor suppressive effect on hepatocellular carcinoma and other solid tumors of epithelial origin. Naturally occurring mutations in this gene are associated with a pyridoxine-dependent epilepsy. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328195
  • ENSP00000333551
  • ENSG00000147471

Symbol
  • PROSC
  • PROSC
  • EPVB6D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.15   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.15   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyridoxal phosphate binding protein
VGNC:14812
472738
Mouse
MGI:1891207
114863
Rat
RGD:1308962
306544
Horse
pyridoxal phosphate binding protein
VGNC:21590
100059780
Cow
pyridoxal phosphate binding protein
VGNC:33043
509643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyridoxal phosphate binding protein
Mouse
Rat
Horse
pyridoxal phosphate binding protein
Cow
pyridoxal phosphate binding protein
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (85)
1 – 10 of 85
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
p_int: 0.999941832
p_ni: 0.000058166
p_wrong: 2e-9
Score: 0.191
Data Source: BioPlex,STRINGDB
OXNAD1
Tdark
Family: Enzyme
Novelty: 1.38777329
p_int: 0.996418182
p_ni: 0.000839887
p_wrong: 0.00274193
Score: 0.37
Data Source: BioPlex,STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
p_int: 0.996418182
p_ni: 0.000839887
p_wrong: 0.00274193
Score: 0.189
Data Source: BioPlex,STRINGDB
CDK5R1
Tchem
Family: Enzyme
Novelty: 0.01065962
p_int: 0.98130283
p_ni: 0.016356483
p_wrong: 0.002340687
Score: 0.211
Data Source: BioPlex,STRINGDB
SLC25A32
Tbio
Family: Transporter
Novelty: 0.06270404
p_int: 0.98130283
p_ni: 0.016356483
p_wrong: 0.002340687
Score: 0.188
Data Source: BioPlex,STRINGDB
FCGR2A
Tbio
Novelty: 0.00078918
p_int: 0.98130283
p_ni: 0.016356483
p_wrong: 0.002340687
Score: 0.187
Data Source: BioPlex,STRINGDB
CARS
Tbio
Family: Enzyme
Novelty: 0.02078279
Score: 0.894
Data Source: STRINGDB
ERLIN2
Tbio
Novelty: 0.04060163
Score: 0.891
Data Source: STRINGDB
RAB11FIP1
Tbio
Novelty: 0.0445306
Score: 0.869
Data Source: STRINGDB
ZNF703
Tbio
Novelty: 0.03956045
Score: 0.819
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.15

PubMed score by year
PubTator Score  6.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer