Protein Summary
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]
- ENST00000328668
- ENSP00000333395
- ENSG00000183876
- ENST00000515301
- ENSP00000426879
- ASI
- SPG66
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.59 | ||
protein domain | 0.58 | ||
PubMedID | 0.58 | ||
histone modification site profile | 0.49 | ||
disease | 0.46 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.57 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 167 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.57 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 167 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (8)
Reactome (8)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (4)
Functions (2)
Components (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | HGNC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (36)
1 – 10 of 36
NOL11
Novelty: 0.72289157
p_int: 0.967184222
p_ni: 0.032815694
p_wrong: 8.4e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
AHCYL2
Family: Enzyme
Novelty: 0.10791598
p_int: 0.866866847
p_ni: 0.133133152
p_wrong: 2e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00051387
p_int: 0.837239914
p_ni: 0.162760086
Score: 0.153
Data Source: BioPlex,STRINGDB
SUMF1
Family: Enzyme
Novelty: 0.01184153
Score: 0.974
Data Source: STRINGDB
SUMF2
Family: Enzyme
Novelty: 0.14379242
Score: 0.952
Data Source: STRINGDB
ARSK
Family: Enzyme
Novelty: 0.05937509
Score: 0.948
Data Source: STRINGDB
ARSH
Family: Enzyme
Novelty: 0.00554685
Score: 0.941
Data Source: STRINGDB
STS
Family: Enzyme
Novelty: 0.0020382
Score: 0.925
Data Source: STRINGDB
ARSE
Family: Enzyme
Novelty: 0.00067857
Score: 0.922
Data Source: STRINGDB
ARSG
Family: Enzyme
Novelty: 0.0408666
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score 111.57
PubMed score by year
PubTator Score 95.72
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIE
1-70
TPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGY
70-140
STHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTM
140-210
LYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWA
210-280
LKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDW
280-350
YPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIR
350-420
VGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLA
420-490
RLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKL
490-560
NTRLMSQRI
560-569
MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSQRI
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