Tbio ARSI Arylsulfatase I

Protein Summary

Description

Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts. This gene encodes a protein that belongs to a large family of sulfatases that hydrolyze sulfate esters and sulfamates. Members of this family play a role in several cellular processes, including hormone synthesis, cell signaling in development and degradation of macromolecules. The protein encoded by this gene is thought to be secreted, and to function in extracellular space. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q5FYB1
• A1L3B0
• B3KV22
• B7XD03
• ASI

Gene Name

• ARSI

Ensembl ID

• ENST00000328668
• ENSP00000333395
• ENSG00000183876
• ENST00000515301
• ENSP00000426879

Symbol

• ASI
• SPG66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.59
protein domain	0.58
PubMedID	0.58
histone modification site profile	0.49
disease	0.46

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.57   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.57   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (8)

Reactome (8)

Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of proteins	2050 targets	R-HSA-392499

Gene Ontology Terms (4)

Functions (2)

Components (2)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
arylsulfatase activity	Traceable Author Statement (TAS)	HGNC
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

NOL11

Tbio

Novelty: 0.72289157

p_int: 0.967184222

p_ni: 0.032815694

p_wrong: 8.4e-8

Score: 0.309

Data Source: BioPlex,STRINGDB

AHCYL2

Tbio

Family: Enzyme

Novelty: 0.10791598

p_int: 0.866866847

p_ni: 0.133133152

p_wrong: 2e-9

Score: 0.223

Data Source: BioPlex,STRINGDB

HSPA5

Tchem

Novelty: 0.00051387

p_int: 0.837239914

p_ni: 0.162760086

Score: 0.153

Data Source: BioPlex,STRINGDB

SUMF1

Tbio

Family: Enzyme

Novelty: 0.01184153

Score: 0.974

Data Source: STRINGDB

SUMF2

Tbio

Family: Enzyme

Novelty: 0.14379242

Score: 0.952

Data Source: STRINGDB

ARSK

Tbio

Family: Enzyme

Novelty: 0.05937509

Score: 0.948

Data Source: STRINGDB

ARSH

Tbio

Family: Enzyme

Novelty: 0.00554685

Score: 0.941

Data Source: STRINGDB

STS

Tchem

Family: Enzyme

Novelty: 0.0020382

Score: 0.925

Data Source: STRINGDB

ARSE

Tbio

Family: Enzyme

Novelty: 0.00067857

Score: 0.922

Data Source: STRINGDB

ARSG

Tbio

Family: Enzyme

Novelty: 0.0408666

Score: 0.921

Data Source: STRINGDB

Publication Statistics

PubMed Score  111.57

PubMed score by year

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PubTator Score  95.72

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIE

1-70

TPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGY

70-140

STHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTM

140-210

LYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWA

210-280

LKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDW

280-350

YPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIR

350-420

VGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLA

420-490

RLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKL

490-560

NTRLMSQRI

560-569

MHTLTGFSLVSLLSFGYLSWDWAKPSFVADGPGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSQRI

Find similar targets by:

Uniprot Keyword

Alternative splicing
Calcium
Complete proteome
Endoplasmic reticulum
Glycoprotein
Hydrolase
Metal-binding
Oxidation
Reference proteome
Secreted