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Tchem
PLA2G6
85/88 kDa calcium-independent phospholipase A2

Protein Classes
Protein Summary
Description
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332509
  • ENSP00000333142
  • ENSG00000184381
  • ENST00000335539
  • ENSP00000335149
  • ENST00000402064
  • ENSP00000386100

Symbol
  • PLPLA9
  • GVI
  • PLA2
  • INAD1
  • NBIA2
  • iPLA2
  • NBIA2A
  • NBIA2B
  • PARK14
  • PNPLA9
  • CaI-PLA2
  • IPLA2-VIA
  • iPLA2beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
0.94
disease perturbation
0.87
trait
0.86
transcription factor binding site profile
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.35   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 443.35   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
6
11
1.5
95.1
high density lipoprotein cholesterol measurement
3
3
4
93.6
body fat percentage
2
2
3
88.9
glomerular filtration rate
4
5
4
6.3
80.2
3
2
0
1.2
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
1.5
95.1
high density lipoprotein cholesterol measurement
4
93.6
body fat percentage
3
88.9
glomerular filtration rate
4
6.3
80.2
0
1.2
77.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group VI
VGNC:9925
470208
Macaque
phospholipase A2 group VI
700184
Mouse
MGI:1859152
53357
Rat
RGD:628867
360426
Dog
phospholipase A2 group VI
VGNC:44631
481256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group VI
Macaque
phospholipase A2 group VI
Mouse
Rat
Dog
phospholipase A2 group VI
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60733-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (31)
Acyl chain remodeling of CL (R-HSA-1482798)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of CL
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of CL
Acyl chain remodelling of PC
Acyl chain remodelling of PE
COPI-independent Golgi-to-ER retrograde traffic
Fcgamma receptor (FCGR) dependent phagocytosis
Gene Ontology Terms (36)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (134)
1 – 10 of 134
PLA2G1B
Tchem
Family: Enzyme
Novelty: 0.00064842
Score: 0.92
Data Source: STRINGDB
PLA2G15
Tbio
Family: Enzyme
Novelty: 0.01546393
Score: 0.888
Data Source: STRINGDB
PLA2G2A
Tchem
Family: Enzyme
Novelty: 0.00105131
Score: 0.876
Data Source: STRINGDB
PNPLA6
Tbio
Family: Enzyme
Novelty: 0.00295195
Score: 0.855
Data Source: STRINGDB
PNPLA7
Tdark
Family: Enzyme
Novelty: 0.11025485
Score: 0.846
Data Source: STRINGDB
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.842
Data Source: STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
Score: 0.842
Data Source: STRINGDB
PLA2G16
Tbio
Novelty: 0.02310886
Score: 0.837
Data Source: STRINGDB
PRKCE
Tchem
Family: Kinase
Novelty: 0.00890161
Score: 0.825
Data Source: STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  443.35

PubMed score by year
PubTator Score  252.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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