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Tbio
WBP2NL
Postacrosomal sheath WW domain-binding protein

Protein Summary
Description
May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328823
  • ENSP00000332983
  • ENSG00000183066
  • ENST00000329620
  • ENSP00000328800
  • ENST00000436265
  • ENSP00000401002

Symbol
  • PAWP
  • PAWP
  • GRAMD7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
histone modification site profile
0.64
gene perturbation
0.56
tissue sample
0.56
virus perturbation
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.43   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.43   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
5.5
58.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
5.5
58.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WBP2 N-terminal like
VGNC:5984
470227
Macaque
WBP2 N-terminal like
709297
Mouse
MGI:1921966
74716
Rat
RGD:1586458
688642
Dog
WBP2 N-terminal like
VGNC:48342
100685691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WBP2 N-terminal like
Macaque
WBP2 N-terminal like
Mouse
Rat
Dog
WBP2 N-terminal like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ICG8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
Protein-Protein Interactions (26)
1 – 10 of 26
ACTR5
Tbio
Novelty: 0.15502033
p_int: 0.9999741
p_ni: 0.000025884
p_wrong: 1.6e-8
Score: 0.534
Data Source: BioPlex,STRINGDB
INO80C
Tdark
Novelty: 0.04242834
p_int: 0.999934022
p_ni: 0.000065967
p_wrong: 1.1e-8
Data Source: BioPlex
OTUD4
Tbio
Novelty: 0.17121119
p_int: 0.998784943
p_ni: 0.001215053
p_wrong: 4e-9
Score: 0.308
Data Source: BioPlex,STRINGDB
PCGF6
Tbio
Novelty: 0.07032909
p_int: 0.994972367
p_ni: 0.005027216
p_wrong: 4.17e-7
Score: 0.543
Data Source: BioPlex,STRINGDB
MGA
Tbio
Family: TF
Novelty: 0.08965274
p_int: 0.982476427
p_ni: 0.017523572
p_wrong: 1e-9
Score: 0.722
Data Source: BioPlex,STRINGDB
FMR1
Tbio
Family: Epigenetic
Novelty: 0.00032203
p_int: 0.867418446
p_ni: 0.132581554
Score: 0.345
Data Source: BioPlex,STRINGDB
PLCZ1
Tbio
Family: Enzyme
Novelty: 0.0059826
Score: 0.796
Data Source: STRINGDB
TXNDC8
Tbio
Novelty: 0.15772943
Score: 0.61
Data Source: STRINGDB
WWP1
Tbio
Family: Enzyme
Novelty: 0.01407874
Score: 0.558
Data Source: STRINGDB
YAP1
Tbio
Novelty: 0.00124225
Score: 0.549
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.43

PubMed score by year
PubTator Score  62.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer