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Tchem
PTGDR2
Prostaglandin D2 receptor 2

Protein Summary
Description
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332539
  • ENSP00000332812
  • ENSG00000183134

Symbol
  • CRTH2
  • DL1R
  • GPR44
  • DP2
  • DL1R
  • CD294
  • CRTH2
  • GPR44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.72
biological term
0.62
molecular function
0.6
phenotype
0.57
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.05   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.05   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1917
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (277)
1 – 10 of 277
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.95
Data Source: STRINGDB
CCL27
Tbio
Novelty: 0.00163457
Score: 0.95
Data Source: STRINGDB
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
Score: 0.949
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.926
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.922
Data Source: STRINGDB
PMCH
Tbio
Novelty: 0.00600873
Score: 0.922
Data Source: STRINGDB
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.92
Data Source: STRINGDB
CXCR3
Tchem
Family: GPCR
Novelty: 0.00100538
Score: 0.917
Data Source: STRINGDB
CCL1
Tbio
Novelty: 0.00379626
Score: 0.916
Data Source: STRINGDB
CCL21
Tbio
Novelty: 0.00130736
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  341.05

PubMed score by year
PubTator Score  194.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer