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Tchem
NPY2R
Neuropeptide Y receptor type 2

Protein Summary
Description
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329476
  • ENSP00000332591
  • ENSG00000185149
  • ENST00000506608
  • ENSP00000426366

Symbol
  • NPY2-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
phenotype
0.87
ligand (chemical)
0.82
kinase perturbation
0.71
cell type or tissue
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.32   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.32   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 101
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y receptor Y2
VGNC:647
461562
Macaque
neuropeptide Y receptor Y2
574149
Mouse
MGI:108418
18167
Rat
RGD:620475
66024
Horse
neuropeptide Y receptor Y2
VGNC:20854
100062115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y receptor Y2
Macaque
neuropeptide Y receptor Y2
Mouse
Rat
Horse
neuropeptide Y receptor Y2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49146-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (312)
1 – 10 of 312
ARFGEF3
Tdark
Novelty: 0.20402365
p_int: 0.999599876
p_ni: 0.000400121
p_wrong: 3e-9
Data Source: BioPlex
ECPAS
Tbio
Novelty: 0.04004664
p_int: 0.999507116
p_ni: 0.000492884
Data Source: BioPlex
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
p_int: 0.999453496
p_ni: 0.000546504
Data Source: BioPlex
HTT
Tchem
Novelty: 0.00034051
p_int: 0.998453296
p_ni: 0.001546704
Data Source: BioPlex
EVI5L
Tbio
Novelty: 0.70769557
p_int: 0.997028748
p_ni: 0.001127386
p_wrong: 0.001843865
Data Source: BioPlex
MZT2B
Tdark
Novelty: 0.69469786
p_int: 0.996325519
p_ni: 0.003669907
p_wrong: 0.000004574
Data Source: BioPlex
RTL8C
Tbio
Novelty: 0.20316911
p_int: 0.995519315
p_ni: 0.004480684
p_wrong: 2e-9
Data Source: BioPlex
DMXL2
Tbio
Novelty: 0.06848356
p_int: 0.994951315
p_ni: 0.005048684
p_wrong: 1e-9
Score: 0.266
Data Source: BioPlex,STRINGDB
SIMC1
Tbio
Novelty: 0.39770049
p_int: 0.994663398
p_ni: 0.005336602
Data Source: BioPlex
NT5C1A
Tbio
Family: Enzyme
Novelty: 0.00634411
p_int: 0.989099946
p_ni: 0.000476237
p_wrong: 0.010423817
Score: 0.167
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  62.32

PubMed score by year
PubTator Score  45.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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