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Tbio
OSBP2
Oxysterol-binding protein 2

Protein Summary
Description
Binds 7-ketocholesterol. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332585
  • ENSP00000332576
  • ENSG00000184792
  • ENST00000401475
  • ENSP00000385254
  • ENST00000437268
  • ENSP00000389200
  • ENST00000438716
  • ENSP00000411052
  • ENST00000446658
  • ENSP00000392080
  • ENST00000535268
  • ENSP00000438713

Symbol
  • KIAA1664
  • ORP4
  • OSBPL4
  • HLM
  • ORP4
  • ORP-4
  • OSBPL1
  • OSBPL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
tissue
0.68
microRNA
0.62
cell line
0.61
phenotype
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.87   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.87   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
94.2
self reported educational attainment
1
1
1
77.7
smoking behaviour measurement
1
1
1
61.7
red blood cell distribution width
1
1
1
21.4
intelligence
1
1
0
5.5
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
94.2
self reported educational attainment
1
77.7
smoking behaviour measurement
1
61.7
red blood cell distribution width
1
21.4
intelligence
0
5.5
9.3
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (60)
1 – 10 of 60
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999999606
p_ni: 4.6e-8
p_wrong: 3.49e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999993642
p_ni: 1.4e-8
p_wrong: 0.000006344
Score: 0.81
Data Source: BioPlex,STRINGDB
BTNL8
Tdark
Novelty: 0.40339869
p_int: 0.9998457
p_ni: 0.000002492
p_wrong: 0.000151808
Score: 0.189
Data Source: BioPlex,STRINGDB
HSCB
Tbio
Novelty: 0.01330125
Score: 0.8
Data Source: STRINGDB
UQCR10
Tbio
Novelty: 0.04536078
Score: 0.749
Data Source: STRINGDB
SLC35A2
Tbio
Family: Transporter
Novelty: 0.00072521
Score: 0.676
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.669
Data Source: STRINGDB
EPB42
Tbio
Family: Enzyme
Novelty: 0.06393286
Score: 0.649
Data Source: STRINGDB
PPIG
Tchem
Family: Enzyme
Novelty: 0.00014569
Score: 0.63
Data Source: STRINGDB
ZRANB3
Tbio
Family: Enzyme
Novelty: 0.00398767
Score: 0.626
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.87

PubMed score by year
PubTator Score  59.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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