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Tbio
SPPL2C
Signal peptide peptidase-like 2C

Protein Summary
Description
Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329196
  • ENSP00000332488
  • ENSG00000185294

Symbol
  • IMP5
  • IMP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.8
cellular component
0.68
cell line
0.67
tissue
0.6
disease
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
80.9
1
1
0
1.3
76.9
Alopecia
1
1
1
71
Corticobasal degeneration
1
1
0
3.5
57
1
1
0
1.3
53.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
80.9
0
1.3
76.9
Alopecia
1
71
Corticobasal degeneration
0
3.5
57
0
1.3
53.8
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal peptide peptidase like 2C
VGNC:12692
468284
Mouse
MGI:3045264
237958
Dog
signal peptide peptidase like 2C
VGNC:46760
490923
Horse
signal peptide peptidase like 2C
VGNC:23537
100146935
Opossum
signal peptide peptidase like 2C [Source:HGNC Symbol;Acc:HGNC:28902]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal peptide peptidase like 2C
Mouse
Dog
signal peptide peptidase like 2C
Horse
signal peptide peptidase like 2C
Opossum
signal peptide peptidase like 2C [Source:HGNC Symbol;Acc:HGNC:28902]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IUH8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (25)
1 – 10 of 25
KANSL1
Tbio
Novelty: 0.03032662
Score: 0.676
Data Source: STRINGDB
KANSL1L
Tdark
Novelty: 0.86034115
Score: 0.666
Data Source: STRINGDB
MYL1
Tbio
Novelty: 0.00360262
Score: 0.628
Data Source: STRINGDB
ADAM11
Tbio
Family: Enzyme
Novelty: 0.122537
Score: 0.603
Data Source: STRINGDB
KANSL3
Tbio
Novelty: 0.00150009
Score: 0.596
Data Source: STRINGDB
ADAM23
Tbio
Family: Enzyme
Novelty: 0.02974247
Score: 0.595
Data Source: STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00101773
Score: 0.581
Data Source: STRINGDB
DPP9
Tchem
Family: Enzyme
Novelty: 0.00976924
Score: 0.575
Data Source: STRINGDB
TOLLIP
Tbio
Novelty: 0.01032371
Score: 0.561
Data Source: STRINGDB
STH
Tbio
Novelty: 0.00564817
Score: 0.55
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.82

PubMed score by year
PubTator Score  4.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer