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Tbio
CARMIL1
F-actin-uncapping protein LRRC16A

Protein Summary
Description
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028). Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329474
  • ENSP00000331983
  • ENSG00000079691

Symbol
  • CARMIL
  • LRRC16
  • LRRC16A
  • CARMIL
  • LRRC16
  • LRRC16A
  • CARMIL1a
  • dJ501N12.1
  • dJ501N12.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.8   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.8   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
6
4
3.7
95
self reported educational attainment
2
2
2
93.1
C-reactive protein measurement
1
1
1
86.3
wellbeing measurement
3
4
6
85.6
4
4
1
1.2
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
3.7
95
self reported educational attainment
2
93.1
C-reactive protein measurement
1
86.3
wellbeing measurement
6
85.6
1
1.2
84.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (25)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (72)
1 – 10 of 72
CAPZA2
Tbio
Novelty: 0.14014918
p_int: 0.999999992
p_ni: 7e-9
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
PAK4
Tchem
Family: Kinase
Novelty: 0.0068821
p_int: 0.999998893
p_ni: 0.000001107
Score: 0.815
Data Source: BioPlex,STRINGDB
PAK5
Tchem
Family: Kinase
Novelty: 0.02138632
p_int: 0.999998665
p_ni: 0.000001335
Score: 0.625
Data Source: BioPlex,STRINGDB
ZPLD1
Tbio
Novelty: 0.19418088
p_int: 0.998638231
p_ni: 0.001361531
p_wrong: 2.37e-7
Score: 0.232
Data Source: BioPlex,STRINGDB
PIANP
Tbio
Novelty: 0.01739512
p_int: 0.997343297
p_ni: 0.002656399
p_wrong: 3.05e-7
Score: 0.241
Data Source: BioPlex,STRINGDB
CAPZB
Tbio
Novelty: 0.03509224
Score: 0.989
Data Source: Reactome,STRINGDB
CAPZA1
Tbio
Novelty: 0.03448517
Score: 0.913
Data Source: Reactome,STRINGDB
TMOD4
Tbio
Novelty: 0.00932697
Score: 0.903
Data Source: STRINGDB
CD2AP
Tbio
Novelty: 0.00603034
Score: 0.844
Data Source: STRINGDB
SLC16A9
Tbio
Family: Transporter
Novelty: 0.06564904
Score: 0.839
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.80

PubMed score by year
PubTator Score  18.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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