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Tbio
DHX34
Probable ATP-dependent RNA helicase DHX34

Protein Summary
Description
Probable ATP-binding RNA helicase. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328771
  • ENSP00000331907
  • ENSG00000134815

Symbol
  • DDX34
  • KIAA0134
  • HRH1
  • DDX34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
transcription factor
0.73
histone modification site profile
0.7
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (142)
1 – 10 of 142
CDPF1
Tdark
Novelty: 0.85714286
p_int: 1
Data Source: BioPlex
UPF1
Tbio
Novelty: 0.00311006
Score: 0.883
Data Source: STRINGDB
SMG9
Tbio
Novelty: 0.03940774
Score: 0.844
Data Source: STRINGDB
DDX49
Tbio
Family: Enzyme
Novelty: 0.14100169
Score: 0.841
Data Source: STRINGDB
SMG8
Tdark
Novelty: 0.18080965
Score: 0.833
Data Source: STRINGDB
UPF3A
Tbio
Novelty: 0.01431609
Score: 0.831
Data Source: STRINGDB
UPF2
Tbio
Novelty: 0.01064562
Score: 0.819
Data Source: STRINGDB
SMG5
Tbio
Novelty: 0.04143189
Score: 0.811
Data Source: STRINGDB
SMG6
Tbio
Family: Enzyme
Novelty: 0.0217417
Score: 0.807
Data Source: STRINGDB
SMG1
Tchem
Family: Kinase
Novelty: 0.00854339
Score: 0.805
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.01

PubMed score by year
PubTator Score  3.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer