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Tbio
COL4A5
Collagen alpha-5(IV) chain

Protein Summary
Description
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328300
  • ENSP00000331902
  • ENSG00000188153
  • ENST00000361603
  • ENSP00000354505

Symbol
  • ATS
  • ASLN
  • ATS1
  • CA54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.88
virus perturbation
0.88
gene perturbation
0.8
small molecule perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.93   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.93   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Axon guidance
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Axon guidance
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Protein-Protein Interactions (149)
1 – 10 of 149
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.999999977
p_ni: 1.5e-8
p_wrong: 8e-9
Score: 0.929
Data Source: BioPlex,STRINGDB
COL8A2
Tbio
Novelty: 0.01672103
p_int: 0.993729678
p_ni: 0.000008699
p_wrong: 0.006261622
Score: 0.985
Data Source: BioPlex,STRINGDB
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.966611754
p_ni: 0.000133964
p_wrong: 0.033254283
Score: 0.979
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.776844563
p_ni: 0.00001036
p_wrong: 0.223145077
Score: 0.914
Data Source: BioPlex,STRINGDB
COL4A6
Tbio
Novelty: 0.02524039
Score: 0.963
Data Source: Reactome,STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.929
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.929
Data Source: STRINGDB
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.928
Data Source: STRINGDB
COL12A1
Tbio
Novelty: 0.0239421
Score: 0.928
Data Source: STRINGDB
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02211629
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  358.93

PubMed score by year
PubTator Score  274.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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