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Tclin
IDH2
Isocitrate dehydrogenase [NADP], mitochondrial

Protein Summary
Description
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript varia ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330062
  • ENSP00000331897
  • ENSG00000182054
  • ENST00000540499
  • ENSP00000446147

Symbol
  • IDH
  • IDP
  • IDHM
  • IDPM
  • ICD-M
  • D2HGA2
  • mNADP-IDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.97
biological term
0.94
PubMedID
0.83
interacting protein
0.81


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.18   (req: < 5)
Gene RIFs: 284   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.18   (req: >= 5)
Gene RIFs: 284   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
enasidenib
chemical structure image
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
VGNC:10254
453645
Macaque
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
701480
Mouse
MGI:96414
269951
Rat
RGD:1597139
361596
Dog
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
VGNC:53183
479043
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Macaque
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Mouse
Rat
Dog
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48735-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Pyruvate metabolism and Citric Acid (TCA) cycle
Protein-Protein Interactions (242)
1 – 10 of 242
KCMF1
Tbio
Family: Enzyme
Novelty: 0.05485534
p_int: 0.999326889
p_ni: 0.000673111
Score: 0.252
Data Source: BioPlex,STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.954576414
p_ni: 0.045423586
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.804178358
p_ni: 0.195821642
Data Source: BioPlex
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.796918195
p_ni: 0.203081689
p_wrong: 1.16e-7
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.766293412
p_ni: 0.233705991
p_wrong: 5.97e-7
Score: 0.196
Data Source: BioPlex,STRINGDB
IDH3G
Tbio
Family: Enzyme
Novelty: 0.04861242
Score: 0.998
Data Source: STRINGDB
IDH3B
Tbio
Family: Enzyme
Novelty: 0.04326765
Score: 0.997
Data Source: STRINGDB
IDH3A
Tbio
Family: Enzyme
Novelty: 0.02027198
Score: 0.997
Data Source: STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.987
Data Source: STRINGDB
ACO2
Tbio
Family: Enzyme
Novelty: 0.00276725
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  701.18

PubMed score by year
PubTator Score  621.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer