You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CALCA
Calcitonin gene-related peptide 1

Protein Classes
Protein Summary
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361010
  • ENSP00000354286
  • ENSG00000110680
  • ENST00000486207
  • ENSP00000417833

Symbol
  • CALC1
  • CT
  • KC
  • PCT
  • CGRP
  • CALC1
  • CGRP1
  • CGRP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
chemical
0.99
protein domain
0.85
PubMedID
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15123.45   (req: < 5)
Gene RIFs: 345   (req: <= 3)
Antibodies: 1657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15123.45   (req: >= 5)
Gene RIFs: 345   (req: > 3)
Antibodies: 1657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
Protein-Protein Interactions (286)
1 – 10 of 286
PHF1
Tbio
Family: Epigenetic
Novelty: 0.00430297
p_int: 0.999635156
p_ni: 0.000152635
p_wrong: 0.000212209
Data Source: BioPlex
DCAF6
Tbio
Novelty: 0.01269552
p_int: 0.986635637
p_ni: 0.013364363
Data Source: BioPlex
GIP
Tchem
Novelty: 0.0007219
p_int: 0.970012506
p_ni: 0.029987236
p_wrong: 2.58e-7
Score: 0.942
Data Source: BioPlex,STRINGDB
CALCB
Tclin
Novelty: 0.02069808
p_int: 0.959087989
p_ni: 8e-9
p_wrong: 0.040912003
Score: 0.909
Data Source: BioPlex,STRINGDB
LRP2
Tbio
Novelty: 0.00143258
p_int: 0.931435932
p_ni: 0.068564068
Data Source: BioPlex
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
p_int: 0.928162743
p_ni: 0.000860859
p_wrong: 0.070976398
Data Source: BioPlex
CALCRL
Tclin
Family: GPCR
Novelty: 0.00568602
Score: 0.995
Data Source: Reactome,STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.992
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.991
Data Source: STRINGDB
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.991
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  15123.45

PubMed score by year
PubTator Score  3544.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: