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Tchem
SELE
E-selectin

Protein Summary
Description
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333360
  • ENSP00000331736
  • ENSG00000007908

Symbol
  • ELAM1
  • ELAM
  • ESEL
  • CD62E
  • ELAM1
  • LECAM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
0.97
chemical
0.92
disease
0.91
cell type or tissue
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3155.32   (req: < 5)
Gene RIFs: 317   (req: <= 3)
Antibodies: 1144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3155.32   (req: >= 5)
Gene RIFs: 317   (req: > 3)
Antibodies: 1144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
79.8
e-selectin measurement
1
1
1
77
monocyte percentage of leukocytes
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
79.8
e-selectin measurement
1
77
monocyte percentage of leukocytes
1
21
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Protein-Protein Interactions (247)
1 – 10 of 247
DIP2B
Tdark
Novelty: 0.14642544
p_int: 0.99922482
p_ni: 0.000751605
p_wrong: 0.000023574
Score: 0.313
Data Source: BioPlex,STRINGDB
DIP2A
Tbio
Novelty: 0.09357918
p_int: 0.987563096
p_ni: 0.012436904
Score: 0.241
Data Source: BioPlex,STRINGDB
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.969552886
p_ni: 0.030447114
Score: 0.177
Data Source: BioPlex,STRINGDB
MTMR1
Tbio
Family: Enzyme
Novelty: 0.06694505
p_int: 0.854893334
p_ni: 0.145106645
p_wrong: 2e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
SBF1
Tbio
Novelty: 0.01814482
p_int: 0.799014943
p_ni: 0.200985035
p_wrong: 2.2e-8
Score: 0.207
Data Source: BioPlex,STRINGDB
SELPLG
Tbio
Novelty: 0.0016359
Score: 0.994
Data Source: Reactome,STRINGDB
CD44
Tbio
Novelty: 0.00011321
Score: 0.989
Data Source: Reactome,STRINGDB
GLG1
Tbio
Novelty: 0.01332149
Score: 0.988
Data Source: Reactome,STRINGDB
SPN
Tbio
Novelty: 0.00121061
Score: 0.968
Data Source: Reactome,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  3155.32

PubMed score by year
PubTator Score  2290.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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