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Tbio
PKP3
Plakophilin-3

Protein Summary
Description
May play a role in junctional plaques. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331563
  • ENSP00000331678
  • ENSG00000184363
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
protein complex
0.84
protein domain
0.73
transcription factor
0.7
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.61   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.61   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
3.1
monocyte count
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
3.1
monocyte count
1
3.1
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (119)
1 – 10 of 119
GDF5
Tbio
Novelty: 0.00218118
p_int: 0.999734341
p_ni: 0.000265657
p_wrong: 2e-9
Data Source: BioPlex
KIF3A
Tbio
Novelty: 0.00555124
p_int: 0.999639701
p_ni: 0.000360242
p_wrong: 5.7e-8
Score: 0.26
Data Source: BioPlex,STRINGDB
RBM24
Tbio
Novelty: 0.04562076
p_int: 0.997821465
p_ni: 0.002177039
p_wrong: 0.000001496
Data Source: BioPlex
GPBP1
Tbio
Novelty: 0.18802498
p_int: 0.99752887
p_ni: 0.002471123
p_wrong: 7e-9
Data Source: BioPlex
OAZ3
Tbio
Family: Enzyme
Novelty: 0.02374168
p_int: 0.996862734
p_ni: 0.003137261
p_wrong: 4e-9
Data Source: BioPlex
SGO2
Tbio
Novelty: 0.05544423
p_int: 0.995934231
p_ni: 0.004065553
p_wrong: 2.16e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.995918013
p_ni: 0.004081987
Data Source: BioPlex
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.993381404
p_ni: 0.006613782
p_wrong: 0.000004813
Data Source: BioPlex
MAPK9
Tchem
Family: Kinase
Novelty: 0.00267199
p_int: 0.990456727
p_ni: 0.009535677
p_wrong: 0.000007596
Score: 0.15
Data Source: BioPlex,STRINGDB
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.990101212
p_ni: 0.009894739
p_wrong: 0.00000405
Data Source: BioPlex
Publication Statistics
PubMed Score  37.61

PubMed score by year
PubTator Score  30.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer