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Tbio
IRX3
Iroquois-class homeodomain protein IRX-3

Protein Summary
Description
Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329734
  • ENSP00000331608
  • ENSG00000177508

Symbol
  • IRXB1
  • IRX-1
  • IRXB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.9
protein domain
0.73
transcription factor binding site profile
0.71
transcription factor
0.68
biological process
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.52   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.52   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
iroquois homeobox 3
VGNC:5816
454091
Mouse
MGI:1197522
16373
Rat
RGD:1307424
307721
Dog
iroquois homeobox 3
VGNC:42102
487277
Horse
iroquois homeobox 3
VGNC:19144
100060667
Species
Name
OMA
EggNOG
Inparanoid
Chimp
iroquois homeobox 3
Mouse
Rat
Dog
iroquois homeobox 3
Horse
iroquois homeobox 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P78415-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
FTO Obesity Variant Mechanism
WikiPathways
FTO Obesity Variant Mechanism
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Farnesoid X Receptor Pathway
WikiPathways
Transcription factor regulation in adipogenesis
Name
Explore in Pharos
Explore in Source
FTO Obesity Variant Mechanism
FTO Obesity Variant Mechanism
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Farnesoid X Receptor Pathway
Transcription factor regulation in adipogenesis
Protein-Protein Interactions (95)
1 – 10 of 95
FTO
Tbio
Family: Enzyme
Novelty: 0.00053473
Score: 0.841
Data Source: STRINGDB
OLIG2
Tbio
Family: TF
Novelty: 0.0015221
Score: 0.739
Data Source: STRINGDB
NKX6-1
Tbio
Family: TF
Novelty: 0.00776559
Score: 0.73
Data Source: STRINGDB
UCP1
Tbio
Novelty: 0.00055954
Score: 0.719
Data Source: STRINGDB
AKAP11
Tbio
Family: Enzyme
Novelty: 0.0685826
Score: 0.712
Data Source: STRINGDB
NKX6-2
Tbio
Family: TF
Novelty: 0.00566832
Score: 0.711
Data Source: STRINGDB
NKX2-2
Tbio
Family: TF
Novelty: 0.00608835
Score: 0.672
Data Source: STRINGDB
DBX2
Tbio
Family: TF
Novelty: 0.11816475
Score: 0.647
Data Source: STRINGDB
HOXB4
Tbio
Family: TF
Novelty: 0.00598207
Score: 0.623
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.62
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.52

PubMed score by year
PubTator Score  43.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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