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Tdark
CYLC1
Cylicin-1

Protein Summary
Description
Possible architectural role during spermatogenesis. May be involved in spermatid differentiation. This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329312
  • ENSP00000331556
  • ENSG00000183035

Symbol
  • CYL
  • CYL1
  • CYCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.55
cellular component
0.54
cell type or tissue
0.45
kinase perturbation
0.42
transcription factor perturbation
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
24.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
24.7
Protein-Protein Interactions (40)
1 – 10 of 40
CCIN
Tbio
Novelty: 0.05318622
Score: 0.931
Data Source: STRINGDB
RPS6KA6
Tchem
Family: Kinase
Novelty: 0.03326451
Score: 0.819
Data Source: STRINGDB
ASB11
Tdark
Novelty: 0.84862254
Score: 0.769
Data Source: STRINGDB
BRWD3
Tbio
Family: Epigenetic
Novelty: 0.08846384
Score: 0.711
Data Source: STRINGDB
ARL13A
Tdark
Family: Enzyme
Novelty: 0.19381742
Score: 0.686
Data Source: STRINGDB
TENT5D
Tbio
Novelty: 0.1864027
Score: 0.675
Data Source: STRINGDB
CFAP47
Tdark
Novelty: 0.59170159
Score: 0.674
Data Source: STRINGDB
AFF2
Tbio
Family: TF
Novelty: 0.00306577
Score: 0.65
Data Source: STRINGDB
QKI
Tbio
Novelty: 0.00966983
Score: 0.645
Data Source: STRINGDB
SPACA5
Tdark
Family: Enzyme
Novelty: 0.19829871
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.16

PubMed score by year
PubTator Score  2.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer