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Tbio
GAST
Gastrin

Protein Summary
Description
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329402
  • ENSP00000331358
  • ENSG00000184502

Symbol
  • GAS
  • GAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.95
gene perturbation
0.81
chemical
0.77
biological term
0.51
cell line
0.47


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8605.86   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8605.86   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gastrin
VGNC:12143
468262
Mouse
MGI:104768
14459
Rat
RGD:2662
25320
Dog
gastrin
VGNC:41121
100685087
Horse
gastrin
VGNC:49456
100034214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gastrin
Mouse
Rat
Dog
gastrin
Horse
gastrin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01350-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (159)
G alpha (q) signalling events (R-HSA-416476)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Gastrin-CREB signalling pathway via PKC and MAPK
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (q) signalling events
GPCR downstream signalling
Gastrin-CREB signalling pathway via PKC and MAPK
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (287)
1 – 10 of 287
GTSE1
Tbio
Family: Enzyme
Novelty: 0.0460569
p_int: 0.999999573
p_ni: 3.7e-8
p_wrong: 3.9e-7
Score: 0.67
Data Source: BioPlex,STRINGDB
BCAR3
Tbio
Novelty: 0.05420404
p_int: 0.999999408
p_ni: 5.86e-7
p_wrong: 6e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
PCDHB16
Tdark
Novelty: 0.67206411
p_int: 0.99997316
p_ni: 0.000026764
p_wrong: 7.6e-8
Data Source: BioPlex
XAGE3
Tdark
Novelty: 0.1418603
p_int: 0.999961321
p_ni: 0.000038679
Score: 0.558
Data Source: BioPlex,STRINGDB
CROCCP2
Tdark
p_int: 0.999902978
p_ni: 0.000097021
Data Source: BioPlex
ATE1
Tbio
Family: Enzyme
Novelty: 0.01672896
p_int: 0.997887773
p_ni: 0.002112227
Score: 0.181
Data Source: BioPlex,STRINGDB
ZZEF1
Tdark
Novelty: 0.33216648
p_int: 0.996653606
p_ni: 0.003346394
Data Source: BioPlex
ZER1
Tbio
Novelty: 0.02989698
p_int: 0.926736422
p_ni: 0.073263577
p_wrong: 1e-9
Data Source: BioPlex
NME2P1
Tdark
Family: Kinase
p_int: 0.878009402
p_ni: 0.121990572
p_wrong: 2.7e-8
Data Source: BioPlex
HECTD3
Tdark
Family: Enzyme
Novelty: 2.20874654
p_int: 0.772394275
p_ni: 0.227605725
Data Source: BioPlex
Publication Statistics
PubMed Score  8605.86

PubMed score by year
PubTator Score  5778.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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