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Tbio
BCAN
Brevican core protein

Protein Summary
Description
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329117
  • ENSP00000331210
  • ENSG00000132692
  • ENST00000361588
  • ENSP00000354925

Symbol
  • BEHAB
  • CSPG7
  • BEHAB
  • CSPG7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
pathway
0.67
PubMedID
0.67
cellular component
0.66
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.04   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.04   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (23)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (110)
1 – 10 of 110
VCAN
Tbio
Novelty: 0.00110986
p_int: 0.99999445
p_ni: 0.000005493
p_wrong: 5.7e-8
Score: 0.972
Data Source: BioPlex,STRINGDB
ULK3
Tchem
Family: Kinase
Novelty: 0.0783598
p_int: 0.99997977
p_ni: 3.5e-8
p_wrong: 0.000020195
Score: 0.622
Data Source: BioPlex,STRINGDB
CCNYL1
Tdark
Novelty: 0.45350824
p_int: 0.98083866
p_ni: 0.019155339
p_wrong: 0.000006002
Score: 0.234
Data Source: BioPlex,STRINGDB
ADAMTS4
Tchem
Family: Enzyme
Novelty: 0.00424194
Score: 0.976
Data Source: STRINGDB
CSPG4
Tbio
Novelty: 0.0038499
Score: 0.967
Data Source: STRINGDB
CSPG5
Tbio
Novelty: 0.01629685
Score: 0.963
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.956
Data Source: STRINGDB
ADAMTS5
Tchem
Family: Enzyme
Novelty: 0.00364004
Score: 0.956
Data Source: STRINGDB
BGN
Tbio
Novelty: 0.00139486
Score: 0.955
Data Source: STRINGDB
CHPF
Tbio
Family: Enzyme
Novelty: 0.02590604
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  130.04

PubMed score by year
PubTator Score  20.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer