You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
OPCML
Opioid-binding protein/cell adhesion molecule

Protein Summary
Description
Binds opioids in the presence of acidic lipids; probably involved in cell contact. This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331898
  • ENSP00000330862
  • ENSG00000183715
  • ENST00000374778
  • ENSP00000363910
  • ENST00000524381
  • ENSP00000434750
  • ENST00000541867
  • ENSP00000445496
  • ENST00000612177
  • ENSP00000482061

Symbol
  • IGLON1
  • OBCAM
  • OPCM
  • OBCAM
  • IGLON1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
disease
0.74
microRNA
0.74
protein domain
0.73
phenotype
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.95   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.95   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
2
4
91.8
self reported educational attainment
1
2
2
77.6
body mass index
1
1
1
70.4
1
1
0
1.1
61.3
cognitive function measurement
1
1
1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
91.8
self reported educational attainment
2
77.6
body mass index
1
70.4
0
1.1
61.3
cognitive function measurement
1
57.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (211)
1 – 10 of 211
NTM
Tbio
Novelty: 0.01659865
p_int: 0.999999999
p_ni: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
MBLAC2
Tdark
Family: Enzyme
Novelty: 0.47407992
p_int: 0.998094277
p_ni: 0.001905722
p_wrong: 1e-9
Data Source: BioPlex
TRIP12
Tbio
Family: Enzyme
Novelty: 0.03433452
p_int: 0.957055449
p_ni: 0.029848371
p_wrong: 0.01309618
Score: 0.254
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.956126819
p_ni: 0.043873181
Score: 0.185
Data Source: BioPlex,STRINGDB
CANX
Tbio
Novelty: 0.00087002
p_int: 0.896910576
p_ni: 0.103089424
Score: 0.154
Data Source: BioPlex,STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.865036278
p_ni: 0.134963722
Data Source: BioPlex
NCAM1
Tbio
Novelty: 0.00020994
p_int: 0.855374904
p_ni: 0.144625096
Score: 0.406
Data Source: BioPlex,STRINGDB
FBXO2
Tbio
Novelty: 0.01578361
p_int: 0.770612476
p_ni: 0.229387469
p_wrong: 5.4e-8
Score: 0.577
Data Source: BioPlex,STRINGDB
NEGR1
Tbio
Novelty: 0.0088917
Score: 0.945
Data Source: STRINGDB
LY6H
Tbio
Novelty: 0.10210816
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.95

PubMed score by year
PubTator Score  41.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: