Protein Classes
Protein Summary
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206). The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, J ...more
- ENST00000328963
- ENSP00000330696
- ENSG00000089041
- ENST00000535250
- ENSP00000442572
- ENST00000535600
- ENSP00000442470
- ENST00000541022
- ENSP00000441230
- ENST00000541716
- ENSP00000437729
- P2X7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
disease | 0.8 | ||
phenotype | 0.68 | ||
biological term | 0.66 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1073.38 (req: < 5)
Gene RIFs: 353 (req: <= 3)
Antibodies: 368 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1073.38 (req: >= 5)
Gene RIFs: 353 (req: > 3)
Antibodies: 368 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 77
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2078
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (2078)
1 – 10 of 2078
Pathways (12)
Reactome (9)
KEGG (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Elevation of cytosolic Ca2+ levels | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Elevation of cytosolic Ca2+ levels | ||||
Hemostasis | ||||
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Gene Ontology Terms (90)
Functions (7)
Components (13)
Processes (70)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Protein-Protein Interactions (95)
1 – 10 of 95
PANX1
Family: IC
Novelty: 0.00209499
Score: 0.992
Data Source: Reactome,STRINGDB
P2RX4
Family: IC
Novelty: 0.00292374
Score: 0.94
Data Source: STRINGDB
P2RX5
Family: IC
Novelty: 0.02646451
Score: 0.936
Data Source: STRINGDB
P2RX1
Family: IC
Novelty: 0.00376724
Score: 0.934
Data Source: STRINGDB
P2RX2
Family: IC
Novelty: 0.00308345
Score: 0.919
Data Source: STRINGDB
P2RX6
Family: IC
Novelty: 0.03263451
Score: 0.916
Data Source: STRINGDB
P2RX3
Family: IC
Novelty: 0.00216381
Score: 0.91
Data Source: STRINGDB
NLRP3
Novelty: 0.00042021
Score: 0.836
Data Source: STRINGDB
P2RY2
Family: GPCR
Novelty: 0.00178586
Score: 0.8
Data Source: STRINGDB
CASP1
Family: Enzyme
Novelty: 0.00043112
Score: 0.775
Data Source: STRINGDB
Publication Statistics
PubMed Score 1073.38
PubMed score by year
PubTator Score 895.28
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAE
1-70
VKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWM
70-140
DPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILP
140-210
GLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDD
210-280
KTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVF
280-350
IDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
350-420
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPES
420-490
HRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGS
490-560
QDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
560-595
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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