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Tbio
SOX1
Transcription factor SOX-1

Protein Summary
Description
Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330949
  • ENSP00000330218
  • ENSG00000182968
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.62
PubMedID
0.61
biological process
0.56
molecular function
0.56
microRNA
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.85   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.85   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
92.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
92.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98357
20664
Cow
SRY-box 1
VGNC:35140
618135
Opossum
SRY-box 1
100016999
Anole lizard
SRY-box 1
100558467
Xenopus
SRY-box 1
XB-GENE-1018269
779569
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
SRY-box 1
Opossum
SRY-box 1
Anole lizard
SRY-box 1
Xenopus
SRY-box 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00570-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (121)
1 – 10 of 121
SOX5
Tbio
Family: TF
Novelty: 0.00623121
p_int: 0.990679215
p_wrong: 0.009320785
Score: 0.574
Data Source: BioPlex,STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.858
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.821
Data Source: STRINGDB
NES
Tbio
Novelty: 0.00035379
Score: 0.808
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.767
Data Source: STRINGDB
OTX2
Tbio
Family: TF
Novelty: 0.0024536
Score: 0.728
Data Source: STRINGDB
FOXA2
Tbio
Family: TF
Novelty: 0.00244521
Score: 0.721
Data Source: STRINGDB
POU3F2
Tbio
Family: TF
Novelty: 0.00649458
Score: 0.72
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.715
Data Source: STRINGDB
NEUROG2
Tbio
Family: TF
Novelty: 0.00489481
Score: 0.685
Data Source: STRINGDB
Publication Statistics
PubMed Score  199.85

PubMed score by year
PubTator Score  78.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer