You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HIST1H1B
Histone H1.5

Protein Summary
Description
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331442
  • ENSP00000330074
  • ENSG00000184357

Symbol
  • H1F5
  • H1
  • H1B
  • H1.5
  • H1F5
  • H1s-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
interacting protein
0.99
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.78
cellular component
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.76   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.76   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1
69.5
low density lipoprotein cholesterol measurement
1
1
1
33.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
69.5
low density lipoprotein cholesterol measurement
1
33.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member b
VGNC:14362
471906
Macaque
-
Mouse
MGI:1861461
56702
Rat
RGD:1590638
680522
Zebrafish
ZDB-GENE-050522-103
553782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member b
Macaque
-
Mouse
Rat
Zebrafish
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P16401-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (134)
1 – 10 of 134
DGKZ
Tbio
Family: Enzyme
Novelty: 0.01312044
p_int: 0.999426139
p_ni: 0.00056626
p_wrong: 0.0000076
Data Source: BioPlex
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.995415958
p_ni: 0.003897681
p_wrong: 0.000686362
Data Source: BioPlex
MAPK9
Tchem
Family: Kinase
Novelty: 0.00267199
p_int: 0.986333798
p_ni: 0.013646689
p_wrong: 0.000019513
Score: 0.234
Data Source: BioPlex,STRINGDB
USP6NL
Tbio
Novelty: 0.09667588
p_int: 0.978899599
p_ni: 0.020838463
p_wrong: 0.000261938
Data Source: BioPlex
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.965136219
p_ni: 0.008011981
p_wrong: 0.0268518
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.964873567
p_ni: 0.035105419
p_wrong: 0.000021015
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.9640076
p_ni: 0.020170476
p_wrong: 0.015821924
Data Source: BioPlex
SYT16
Tbio
Novelty: 0.05270686
p_int: 0.933640553
p_ni: 0.020078233
p_wrong: 0.046281214
Score: 0.189
Data Source: BioPlex,STRINGDB
B3GALNT1
Tbio
Family: Enzyme
Novelty: 0.01235828
p_int: 0.925285859
p_ni: 0.006112249
p_wrong: 0.068601892
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.9079338
p_ni: 0.011723985
p_wrong: 0.080342215
Data Source: BioPlex
Publication Statistics
PubMed Score  507.76

PubMed score by year
PubTator Score  1470.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer